Isoflurane is an inhaled anesthetic with the chemical name 2-chloro-2- (difluoromethoxy) -1,1,1-trifluoroethane and the molecular formula C3H2ClF5O. It is a colorless and transparent liquid, easily volatile, soluble in organic solvents but insoluble in water, with a relative density of 1.495-1.510, a distillation range of 47-50 ℃, and a refractive index of 1.2990-1.3005. This drug belongs to the isomer of Enflurane, which induces anesthesia and awakens quickly, and has little effect on myocardial contractility and liver and kidney function. It inhibits the central nervous system to produce anesthetic effects, making it suitable for inducing and maintaining general anesthesia, as well as for labor anesthesia. Blood pressure and respiratory status should be monitored during use, and contraindications include patients with a history of malignant hyperthermia and pregnant women (excluding cesarean section). Adverse reactions mainly include hypotension, respiratory depression, occasional laryngeal spasms or vomiting. The commonly used concentration of oxygen mixture in clinical practice is 0.5% -3%, and 1% -2.5% concentration is often used to maintain anesthesia.

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Isoflurane

Isoflurane Manufacturers, CP, USP, EP Isoflurane, GMP , ODMF, API and FDF, export to all over the world. Isoflurane CAS No. 26675-46-7, is an organic compound, which belongs to inhalation general anesthesia. It is clinically applicable to surgical anesthesia for patients with epilepsy, diabetes and bronchial asthma. It is a colorless and transparent liquid with a boiling point of 48.5 ℃ and a refractive index of 1.301. It is insoluble in water and needs to be stored in a cool, light shielded and sealed place

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Isoflurane, an intriguing halogenated ether possessing notable anesthetic attributes, has been a subject of scientific fascination. While the intricate intricacies of isoflurane’s anesthetic mechanisms continue to elude complete comprehension, recent investigations into its effects on mice have unveiled some intriguing insights. Mice endowed with an inherent resistance to the sedative charms of isoflurane display a remarkable 86% reduction in the expression of the gene responsible for encoding the GABAA receptor subunit β1, in stark contrast to their more susceptible counterparts. This peculiar finding suggests a plausible involvement of the GABAA receptor in orchestrating isoflurane’s hypnotic influence.

In the realm of murine experimentation, it has been discerned that the administration of isoflurane at a concentration of 1.5% over a span of 4 hours exerts a discernible impact on spatial recognition memory. Evidently, in both the spontaneous alternation test and the enigmatic Y-maze, the cognitive faculties of the mice experience impairment subsequent to exposure to isoflurane. Notably, this impairment lingers persistently for a minimum duration of 24 hours. Remarkably, the molecular landscape also experiences alteration, as levels of phosphorylated Jnk1/2 register a noticeable elevation during this timeframe, thus adding another layer of complexity to the aftereffects of isoflurane.

The application of formulations infused with isoflurane has established a noteworthy presence in the realm of anesthetics, lending credence to its enduring relevance and utility in medical practice.

Finding Isoflurane Manufacturers and Suppliers in China

Finding a trustful partner in our business is one of the biggest challenges and to overcome that challenge and to make one’s work/life easy in finding the trusted manufacturer and supplier of Isoflurane, one can visit the Pipelinepharma website which helps you in finding the trusted manufacturers and suppliers of Isoflurane. Kunxiangda is a leading supplier of Isoflurane in China, providing high quality products at the lowest price. Connect with qualified manufacturers.

Technical Information

Chemical name: 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether

Molecular formula: c3h2clf5o

Molecular weight: 184.49

GMP certificate CFDA

Storage: -20°C

Shipping: Room Temperature in continental US; may vary elsewhere

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