Isoflurane Manufacturers
Isoflurane, an intriguing halogenated ether possessing notable anesthetic attributes, has been a subject of scientific fascination. While the intricate intricacies of isoflurane’s anesthetic mechanisms continue to elude complete comprehension, recent investigations into its effects on mice have unveiled some intriguing insights. Mice endowed with an inherent resistance to the sedative charms of isoflurane display a remarkable 86% reduction in the expression of the gene responsible for encoding the GABAA receptor subunit β1, in stark contrast to their more susceptible counterparts. This peculiar finding suggests a plausible involvement of the GABAA receptor in orchestrating isoflurane’s hypnotic influence.
In the realm of murine experimentation, it has been discerned that the administration of isoflurane at a concentration of 1.5% over a span of 4 hours exerts a discernible impact on spatial recognition memory. Evidently, in both the spontaneous alternation test and the enigmatic Y-maze, the cognitive faculties of the mice experience impairment subsequent to exposure to isoflurane. Notably, this impairment lingers persistently for a minimum duration of 24 hours. Remarkably, the molecular landscape also experiences alteration, as levels of phosphorylated Jnk1/2 register a noticeable elevation during this timeframe, thus adding another layer of complexity to the aftereffects of isoflurane.
The application of formulations infused with isoflurane has established a noteworthy presence in the realm of anesthetics, lending credence to its enduring relevance and utility in medical practice.
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Technical Information
Chemical name: 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether
Molecular formula: c3h2clf5o
Molecular weight: 184.49
GMP certificate CFDA
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere