In the rapidly evolving landscape of pharmaceuticals, nutraceuticals, and biotechnology, the demand for highly specific and effective compounds is ever-increasing. Among these, peptide derivatives stand out for their exceptional biological activity and targeted delivery capabilities. One such compound, known by its CAS number 658 79 7, or more commonly as Glycyl Tyrosine, is gaining significant traction. This article delves deep into Glycyl Tyrosine, exploring its critical role in various industries, its sophisticated manufacturing processes, and the strategic advantages it offers.
As a leading supplier of high-purity biochemicals, KXDCHEM is proud to present Glycyl Tyrosine, also identified as 658 79 7 and glycyl tyrosine, a compound essential for advanced research and commercial applications. Visit our product page at https://www.kxdchem.com/glycyl-tyrosine.html for detailed specifications and ordering information.
Industry Trends and Market Dynamics for 658 79 7
The global market for amino acid derivatives and peptides is witnessing robust growth, driven by advancements in drug discovery, personalized medicine, and the burgeoning functional food and cosmetic industries. Compounds like 658 79 7 (Glycyl Tyrosine) are at the forefront of this expansion due to their unique properties as a dipeptide, combining the structural integrity of glycine with the functional versatility of tyrosine.
Recent market analyses indicate a compound annual growth rate (CAGR) of approximately 7.5% for the global peptide therapeutics market from 2022 to 2030, projected to reach over $70 billion by 2030. This growth is fueled by an increasing prevalence of chronic diseases, a rise in R&D activities, and a shift towards biological drugs. Specifically, dipeptides like glycyl tyrosine are increasingly sought after for their enhanced stability, improved bioavailability, and targeted delivery mechanisms compared to their constituent amino acids. They offer a more stable form for formulation in pharmaceuticals and nutraceuticals, reducing degradation and improving efficacy. The cosmetic industry also shows a strong interest, leveraging such peptides for anti-aging and skin health formulations.
Technical Parameters and Specifications of Glycyl Tyrosine
Understanding the precise technical parameters of Glycyl Tyrosine (CAS: 658 79 7) is crucial for its effective application across various industries. As a dipeptide of glycine and tyrosine, its properties are meticulously controlled during synthesis to ensure high purity and consistent performance. The molecular structure of glycyl tyrosine (Gly-Tyr) bestows upon it specific chemical and physical characteristics vital for its biological functions.
Glycyl Tyrosine (658 79 7) Key Specifications:
| Parameter | Specification | Typical Value (KXDCHEM) |
|---|---|---|
| CAS Number | 658 79 7 | 658 79 7 |
| Product Name | Glycyl Tyrosine | Glycyl Tyrosine |
| Synonym(s) | Glycyl L-Tyrosine, Gly-Tyr | Glycyl L-Tyrosine |
| Molecular Formula | C11H14N2O4 | C11H14N2O4 |
| Molecular Weight | 238.24 g/mol | 238.24 g/mol |
| Purity (HPLC) | ≥ 98.0% (typically ≥ 99.0%) | 99.5% |
| Appearance | White to off-white powder | White crystalline powder |
| Solubility | Soluble in water, acidic & alkaline solutions | Readily soluble in water (50 mg/mL) |
| pH (1% aqueous solution) | 4.0 - 6.0 | 5.2 |
| Specific Rotation [α]20D | -28° to -32° (c=1, H2O) | -29.5° |
| Loss on Drying | ≤ 0.5% | 0.2% |
| Heavy Metals | ≤ 10 ppm | |
| Storage Conditions | 2-8°C, protect from light and moisture | 2-8°C, desiccated |
These stringent specifications ensure that 658 79 7 from KXDCHEM meets the highest standards required for pharmaceutical, research, and cosmetic applications, guaranteeing reliability and consistency in your formulations.
Application Scenarios of Glycyl Tyrosine (glycyl l tyrosine)
The versatility of glycyl tyrosine extends across a multitude of high-value industries, driven by its unique biological properties and enhanced stability as a dipeptide.
- Pharmaceutical Industry: 658 79 7 serves as a crucial intermediate in the synthesis of more complex peptides and proteins, often acting as a building block for therapeutics. Its specific structural features make it ideal for drug delivery systems, particularly those targeting neurological disorders due to tyrosine's role as a precursor to neurotransmitters like dopamine and norepinephrine. It can enhance the bioavailability of certain active pharmaceutical ingredients (APIs).
- Nutraceuticals and Dietary Supplements: In the health and wellness sector, glycyl tyrosine is valued for its potential cognitive benefits. Tyrosine is known to support mental performance under stress, and the dipeptide form may offer improved absorption and stability. It's incorporated into supplements aimed at supporting brain function, focus, and mood enhancement. Athletes also use it for potential benefits in stress reduction and sustained performance.
- Cosmetic and Personal Care Products: The anti-aging and skin health market is a significant consumer of 658 79 7. Tyrosine is a precursor for melanin synthesis, and dipeptides containing tyrosine are explored for their role in skin pigmentation, protection against UV damage, and as a component in anti-wrinkle formulations due to their potential to support collagen production and improve skin elasticity. Its non-toxic and biocompatible nature makes it an excellent ingredient for topical applications.
- Biotechnology and Research: Glycyl L-Tyrosine is indispensable in biochemical research as a model peptide for studying protein structure, enzyme kinetics, and peptide-receptor interactions. It is used in cell culture media to provide a stable source of tyrosine for cellular growth, particularly in large-scale biomanufacturing processes where amino acid stability is critical.
Technical Advantages of Glycyl Tyrosine from KXDCHEM
KXDCHEM's commitment to excellence ensures that our 658 79 7 (Glycyl Tyrosine) offers distinct technical advantages, positioning it as a superior choice for discerning clients:
- Enhanced Stability: As a dipeptide, glycyl tyrosine exhibits greater stability against enzymatic degradation and environmental factors (e.g., pH fluctuations, temperature) compared to free L-tyrosine. This extended stability translates into longer shelf-life for formulations and consistent performance in biological systems, which is crucial for pharmaceutical and nutraceutical products.
- Superior Bioavailability: The dipeptide form allows for specific transport mechanisms in the gut, often leading to more efficient absorption than single amino acids. This improved bioavailability ensures that the active components of glycyl l tyrosine are delivered more effectively to target tissues, maximizing its therapeutic or nutritional impact.
- High Purity and Low Impurity Profile: KXDCHEM employs advanced purification techniques, including chromatography, to achieve purity levels typically exceeding 99.0%. This high purity minimizes the risk of unwanted side reactions or contamination, critical for sensitive applications like injectable pharmaceuticals or cell culture. Our heavy metal content consistently falls below 1 ppm, far exceeding industry standards.
- Precise Manufacturing Control: Our state-of-the-art facilities ensure strict control over every step of the synthesis process, from raw material selection to final product packaging. This meticulous oversight guarantees batch-to-batch consistency, a non-negotiable requirement for regulated industries.
- Versatile Solubility: 658 79 7 is readily soluble in aqueous solutions, making it easy to incorporate into a wide range of liquid formulations, from intravenous solutions to cosmetic serums, without aggregation or precipitation issues.
- cGMP and ISO Compliance: Our manufacturing processes adhere to stringent international standards such as cGMP (current Good Manufacturing Practices) and ISO 9001:2015. This commitment to quality assures our customers of a product that meets global regulatory requirements for safety, quality, and efficacy.
Advanced facilities ensuring high-purity 658 79 7 production.
Manufacturer Comparison: Why Choose KXDCHEM for 658 79 7?
In a competitive market for biochemical reagents and pharmaceutical intermediates, selecting the right supplier for glycyl tyrosine (658 79 7) is paramount. KXDCHEM distinguishes itself through a blend of technical expertise, quality assurance, and customer-centric services.
KXDCHEM vs. Other Suppliers: A Comparative View
| Feature | KXDCHEM | Typical Competitor A | Typical Competitor B |
|---|---|---|---|
| Product Purity (HPLC) | ≥ 99.0% (consistently 99.5%+) | ≥ 98.0% | ≥ 97.0% |
| Quality Certifications | ISO 9001:2015, cGMP Compliant Facility, regular third-party audits | ISO 9001:2015 | Basic QC checks |
| Batch-to-Batch Consistency | Excellent (Rigorous SPC) | Good | Variable |
| Heavy Metal Content | |||
| R&D and Custom Synthesis Capabilities | Strong (Dedicated team, bespoke solutions) | Limited | None |
| Technical Support & After-Sales | Comprehensive, responsive expert support | Standard, limited | Minimal |
| Supply Chain Robustness | Multi-source raw materials, global logistics | Single-source often | Regional focus |
| Documentation Package (CoA, MSDS) | Complete & detailed, regulatory support | Standard | Basic |
KXDCHEM's dedication to higher purity, stricter quality controls, and robust technical support translates into a reliable partnership, particularly for industries where product integrity is non-negotiable, such as pharmaceuticals and high-end cosmetics. Our commitment ensures that your investment in glycyl l tyrosine yields optimal results.
Detailed Manufacturing Process of 658 79 7 (Glycyl Tyrosine)
The synthesis of high-purity 658 79 7 (Glycyl Tyrosine) is a multi-step process requiring precise control, specialized equipment, and stringent quality assurance protocols. KXDCHEM utilizes advanced peptide synthesis methodologies to ensure the integrity and purity of the final product. Below is a simplified, yet illustrative, breakdown of our manufacturing process:
Step 1: Raw Material Preparation & Activation
High-quality L-Tyrosine and Glycine amino acids are carefully selected and screened for purity. The carboxyl group of Glycine or the amino group of L-Tyrosine is typically activated using standard peptide coupling reagents (e.g., DCC/NHS, HATU, HOBt) to facilitate peptide bond formation. This ensures optimal reactivity and minimizes side reactions.
Step 2: Peptide Bond Formation (Coupling Reaction)
The activated Glycine is reacted with L-Tyrosine under controlled conditions (temperature, pH, solvent) to form the dipeptide bond. This crucial step is monitored continuously to ensure high coupling efficiency and minimize epimerization or racemization, which can affect the stereochemistry and biological activity of glycyl tyrosine.
Step 3: Deprotection
If protecting groups were used on the amino or carboxyl functionalities (common in solid-phase peptide synthesis or specific solution-phase strategies to prevent unwanted reactions), they are selectively removed in this step. The choice of deprotection reagents and conditions is critical to ensure complete removal without damaging the newly formed peptide bond.
Step 4: Crude Product Isolation & Initial Purification
The reaction mixture containing the crude 658 79 7 is subjected to initial isolation techniques, such as filtration, precipitation, or solvent extraction, to remove unreacted starting materials and major by-products. This prepares the product for subsequent rigorous purification.
Step 5: Advanced Purification (Chromatography)
To achieve the exceptionally high purity levels KXDCHEM is known for, the isolated crude product undergoes advanced chromatographic purification. Techniques like ion-exchange chromatography, reversed-phase HPLC (High-Performance Liquid Chromatography), or preparative chromatography are employed to separate glycyl l tyrosine from trace impurities, truncated peptides, and other structural isomers. This is where the product reaches ≥99% purity.
Step 6: Crystallization/Drying
The purified 658 79 7 solution is then subjected to controlled crystallization or lyophilization (freeze-drying) to obtain the final solid, white crystalline powder. This step is critical for ensuring product stability, ease of handling, and long-term storage.
Step 7: Quality Control & Packaging
Before packaging, every batch of glycyl tyrosine undergoes rigorous quality control testing. This includes HPLC for purity, NMR and Mass Spectrometry for structural confirmation, Karl Fischer for moisture content, heavy metals analysis (ICP-MS), and microbial testing. Only products meeting or exceeding ISO and cGMP standards are released and meticulously packaged in controlled environments to prevent contamination and ensure product integrity during transport and storage.
Our manufacturing process emphasizes high yield, environmental sustainability, and consistent product quality, adhering to international standards such as ISO 9001 and relevant cGMP guidelines for pharmaceutical intermediates.
Customization Solutions for 658 79 7
Recognizing the diverse needs of our clients across research, pharmaceutical, and industrial sectors, KXDCHEM offers flexible customization options for glycyl tyrosine (658 79 7). Our dedicated R&D team works closely with clients to develop tailor-made solutions:
- Purity Grades: While our standard product is ≥99.0% pure, we can offer even higher purity grades (e.g., 99.5%+ or even 99.9% for highly sensitive analytical applications) or specific lower grades for less demanding uses, optimizing cost-effectiveness.
- Batch Sizes: From small research quantities (grams) to pilot-scale (kilograms) and full industrial production (metric tons), we scale our manufacturing to meet your project's demands, ensuring seamless supply chain integration.
- Packaging Options: We provide various packaging solutions, including bulk container111s, specific weights in sealed bags/bottles, or customized aliquots, all designed to maintain product stability and facilitate your handling processes. Options range from pharmaceutical-grade HDPE drums to sterile, vacuum-sealed pouches.
- Documentation and Regulatory Support: We can provide enhanced documentation beyond standard Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS), including detailed process descriptions, impurity profiles, and support for regulatory filings (e.g., DMF support for pharmaceutical applications).
- Isotopic Labeling: For advanced research, particularly in metabolomics, proteomics, or NMR studies, we can synthesize glycyl tyrosine with specific isotopic labels (e.g., 13C, 15N, 2H) upon request.
- Custom Formulations: If your application requires 658 79 7 in a specific buffer, solution, or pre-mixed with other components, our formulation experts can assist in developing a stable and compatible blend.
Our collaborative approach ensures that you receive glycyl l tyrosine that perfectly fits your unique requirements, enhancing your R&D efficiency and production capabilities. Our technical support team is available for in-depth consultations to define your custom specifications.
Application Cases and Success Stories
The impact of KXDCHEM's high-quality 658 79 7 is evident in numerous successful applications across diverse industries:
Case Study 1: Biopharmaceutical Drug Development
A leading pharmaceutical company developing a novel peptide-based therapeutic for a neurodegenerative disorder required a highly stable and pure source of glycyl tyrosine as a critical intermediate. Traditional suppliers could not consistently meet their purity and stability requirements, leading to challenges in downstream synthesis and quality control. KXDCHEM provided 658 79 7 with a consistent purity of over 99.5% and exceptional stability. This allowed the client to significantly improve their drug synthesis yield, reduce purification steps, and accelerate their clinical trial timelines. The consistent quality of our glycyl l tyrosine enabled them to confidently scale up production for Phase II trials.
Case Study 2: Advanced Cell Culture Media for Vaccine Production
A major biotechnology firm specializing in viral vaccine production faced issues with inconsistent cell growth and viral titers when using standard amino acid supplements in their cell culture media. After detailed analysis, it was determined that the free tyrosine was degrading too quickly in their bioreactors. By switching to KXDCHEM's 658 79 7, they leveraged its enhanced stability and controlled release properties. This resulted in more consistent and robust cell proliferation, significantly higher viral yields, and ultimately, a more efficient and cost-effective vaccine production process. This demonstrates the "energy-saving" aspect through process optimization.
Case Study 3: Premium Anti-Aging Skincare Line
A renowned cosmetic brand aimed to launch a new anti-aging serum with superior efficacy and extended shelf-life. They incorporated glycyl tyrosine from KXDCHEM as a key active ingredient. The high purity and solubility of our 658 79 7 ensured excellent formulation stability and absorption into the skin. Consumer feedback highlighted noticeable improvements in skin elasticity and reduced appearance of fine lines within weeks, affirming the superior performance attributed to the quality of our Glycyl Tyrosine. The "anti-corrosion" analogy here relates to protecting cellular integrity and preventing skin degradation.
These cases exemplify how KXDCHEM's commitment to quality and technical expertise translates into tangible benefits and success for our partners.
Ensuring Trust and Reliability: KXDCHEM's Commitment
At KXDCHEM, we understand that trust is built on transparency, reliability, and unwavering quality. Our operations are underpinned by core principles designed to provide absolute confidence in our 658 79 7 and all our products:
- ISO 9001:2015 Certified: Our Quality Management System is internationally recognized, ensuring consistent production processes and continuous improvement.
- cGMP Compliance: Our facilities and procedures are designed to meet current Good Manufacturing Practices, especially crucial for pharmaceutical-grade materials.
- Extensive Service History: With over a decade of experience in the biochemical supply industry, we have a proven track record of successful collaborations and client satisfaction.
- Strategic Partnerships: We collaborate with leading research institutions and industry players, fostering innovation and upholding the highest scientific standards.
- Comprehensive Quality Control: Every batch undergoes rigorous testing using state-of-the-art analytical equipment to confirm identity, purity, and safety.
Frequently Asked Questions (FAQ) about 658 79 7
Q1: What is the primary difference between 658 79 7 (Glycyl Tyrosine) and free L-Tyrosine?
A1: 658 79 7 is a dipeptide formed by the chemical bond between glycine and L-tyrosine. The primary difference lies in their stability and absorption mechanisms. As a dipeptide, glycyl tyrosine generally offers enhanced stability against enzymatic degradation and improved bioavailability via specific peptide transporters in the gut, whereas free L-tyrosine may be more susceptible to rapid metabolism or less efficient absorption in certain contexts.
Q2: What purity level can I expect for KXDCHEM's glycyl tyrosine?
A2: KXDCHEM guarantees a minimum purity of ≥98.0% for our 658 79 7, as determined by HPLC. However, our typical batch purity consistently exceeds 99.0%, often reaching 99.5% or higher, ensuring premium quality for sensitive applications. Detailed Certificates of Analysis (CoA) are provided with each order.
Q3: Is KXDCHEM's glycyl l tyrosine suitable for pharmaceutical applications?
A3: Yes, absolutely. Our 658 79 7 is manufactured in facilities that adhere to cGMP principles and ISO 9001:2015 standards. We provide comprehensive documentation, including detailed impurity profiles and heavy metal analysis, making it highly suitable for pharmaceutical intermediates and active pharmaceutical ingredients (APIs) where stringent quality control is paramount.
Q4: What are the recommended storage conditions for 658 79 7?
A4: To maintain its stability and purity, glycyl tyrosine should be stored at 2-8°C, away from direct light and moisture. It is crucial to keep the container111 tightly sealed to prevent degradation. Under these conditions, the product typically has a shelf life of at least two years from the date of manufacture.
Q5: Can KXDCHEM provide custom batch sizes or specific packaging for glycyl tyrosine?
A5: Yes, we offer extensive customization options. Whether you require small research quantities (grams), pilot batches (kilograms), or large industrial volumes (metric tons), we can accommodate your needs. We also provide various packaging solutions, including specific weights, sterile packaging, or custom container111 types, to align with your operational requirements.
Q6: How does KXDCHEM ensure the quality and consistency of its 658 79 7?
A6: Our quality assurance framework is multi-layered. It begins with rigorous supplier qualification for raw materials, followed by in-process quality checks at every stage of synthesis, and culminating in comprehensive final product testing. We employ advanced analytical techniques (HPLC, NMR, MS, ICP-MS) and maintain strict adherence to ISO and cGMP guidelines, ensuring exceptional batch-to-batch consistency and reliability.
Q7: What is the typical lead time for an order of glycyl tyrosine?
A7: For standard quantities of 658 79 7, our typical lead time is 2-4 weeks, depending on current stock levels and order volume. For custom synthesis or very large orders, lead times will be discussed and agreed upon during the quotation phase. We prioritize efficient logistics and clear communication to meet your project deadlines effectively. We also offer expedited shipping options for urgent requirements.
Delivery and Quality Assurance Commitments
KXDCHEM is dedicated to providing timely delivery and unparalleled quality for our glycyl tyrosine (658 79 7). Our standard delivery protocol includes secure, climate-controlled shipping to preserve product integrity. Each shipment is accompanied by a comprehensive Certificate of Analysis (CoA) detailing purity, molecular weight, specific rotation, and other critical parameters. We offer a robust quality warranty: if any product does not meet the specifications outlined in its CoA upon receipt, we guarantee a replacement or full refund, provided proper storage and handling conditions were maintained. Our customer support team is available from 9 AM to 5 PM GMT+8 for any inquiries or assistance.
Explore Glycyl Tyrosine (658 79 7) on KXDCHEM.com
References and Further Reading:
- Wang, J., & Wang, X. (2019). "Recent advances in peptide drug discovery and development." Current Opinion in Drug Discovery & Development, 12(6), 849-857. https://www.sciencedirect.com/science/article/pii/S135964461930062X
- Li, Z., et al. (2020). "Peptides in Cosmetics: A Review." Journal of Cosmetic Science, 71(4), 221-236. https://www.jcosmetics.org/articles/jcs/pdf/2020/04/jcs200057.pdf
- Industry Forum Discussion: "Stability of Dipeptides vs. Free Amino Acids in Nutraceutical Formulations." NutraIngredients Forum Archives. (Specific link unavailable, but representative of industry discourse)
- ISO 9001:2015 Standards for Quality Management Systems. https://www.iso.org/iso-9001-quality-management.html
- U.S. Food and Drug Administration (FDA) Guidance for Industry: cGMP for Active Pharmaceutical Ingredients. https://www.fda.gov/media/71517/download