The global pharmaceutical landscape is increasingly dependent on high-purity intermediates to ensure the efficacy of life-saving medications. Among these, specific chemical precursors play a pivotal role in synthesizing cardiovascular and antiarrhythmic drugs, acting as the foundational building blocks for complex molecular structures. Understanding the technical specifications and supply chain reliability of these materials is essential for pharmaceutical manufacturers aiming to maintain rigorous quality standards.
In the pursuit of medical innovation, the demand for precise chemical synthesis has led to a greater emphasis on the purity and consistency of pharmaceutical intermediates. The ability to source materials that meet strict regulatory requirements allows labs to accelerate the development of treatments for hypertension and heart failure, reducing the time it takes for critical therapies to reach the global market.
For procurement specialists and researchers, finding a reliable source for bare supplements of chemical intermediates like 6-Chloro-1,3-dimethyluracil is paramount. By focusing on a purity of 98% and adhering to established CAS and EINECS standards, manufacturers can ensure the stability and safety of the final drug products.
Chemical Properties of 6-Chloro-1,3-dimethyluracil
6-Chloro-1,3-dimethyluracil, identified by CAS No. 6972-27-6, is a yellowish crystalline powder characterized by its molecular formula C6H7ClN2O2 and a molecular weight of 174.585. As a high-grade pharmaceutical intermediate, its chemical structure provides the necessary reactivity for the synthesis of critical medication.
Maintaining a purity level of 98% is essential for this compound to function effectively in complex reactions. Its classification as a pyrimidinedione derivative makes it an indispensable component in the creation of specialized APIs, ensuring that the resulting pharmaceuticals are both potent and stable.
Strategic Importance in Drug Synthesis
The strategic value of 6-Chloro-1,3-dimethyluracil lies in its role as a primary intermediate for the synthesis of Urapidil and Nifekalant. Urapidil, a well-known blood pressure lowering drug, relies on this intermediate to achieve the precise molecular configuration required to treat primary renal hypertension and heart failure.
Similarly, the production of Nifekalant, an antiarrhythmic agent, depends on the availability of high-quality 6-chloro-1,3-dimethylpyrimidine-2,4-dione. Without these high-purity "building blocks," the consistency of the final therapeutic product would be compromised, potentially affecting patient outcomes in critical care settings.
By integrating these intermediates into a streamlined manufacturing process, pharmaceutical companies can scale the production of these essential medicines to meet the needs of more than 30 countries, ensuring that patients with cardiovascular disorders have reliable access to treatment.
Quality Control and Purity Standards
In the chemical industry, purity is not just a number but a guarantee of safety. The use of bare supplements of raw materials must be scrutinized through rigorous testing methods such as HPLC and GC to ensure that impurities do not interfere with the final synthesis of the API.
To maintain these standards, technicians provide comprehensive TDS (Technical Data Sheets) and MSDS (Material Safety Data Sheets). This transparency allows clients to verify that the 98% purity of 6-Chloro-1,3-dimethyluracil aligns with the specific requirements of their proprietary drug formulations.
Furthermore, the acceptance of third-party inspections serves as an additional layer of quality assurance. When pharmaceutical companies can verify the identity and purity of their bare supplements via independent laboratories, it fosters a relationship of trust and long-term stability in the supply chain.
Logistics and Global Distribution Efficiency
Efficient logistics are critical for maintaining the integrity of pharmaceutical intermediates. 6-Chloro-1,3-dimethyluracil is typically packaged in 25kg bags, a standard that balances ease of handling with protection against environmental degradation, ensuring the crystalline powder remains stable during transit.
To optimize global shipping, a 20ft FCL (Full Container Load) can accommodate up to 12 metric tons when loaded with pallets. This scalability allows for the rapid movement of materials from Chinese main ports to international hubs, ensuring that drug manufacturing schedules are never interrupted by supply shortages.
Supply Chain Reliability Rating for Chemical Intermediates
Applications in Cardiovascular Medicine
The primary application of 6-Chloro-1,3-dimethyluracil is centered on the fight against chronic cardiovascular conditions. By acting as the core intermediate for Urapidil, it enables the production of a drug that is essential for managing pheochromocytoma and primary renal hypertension, providing critical relief to patients worldwide.
Beyond blood pressure management, its role in the synthesis of Nifekalant highlights its versatility in cardiology. This antiarrhythmic medication is vital for stabilizing heart rhythms, demonstrating how a single chemical intermediate can support multiple therapeutic pathways within the same medical field.
Regulatory Compliance and Safety Data
Adherence to global chemical standards is mandatory for any intermediate used in pharma. 6-Chloro-1,3-dimethyluracil is documented under EINECS NO. 230-205-2 and MFCD00038066, ensuring that every batch can be traced and verified across international borders according to safety protocols.
Safety in handling yellowish crystalline powders requires strict adherence to MSDS guidelines. Proper storage and the use of protective equipment are necessary to maintain the purity of the product and the safety of the technicians involved in the synthesis process.
Furthermore, the ability to provide customized specifications based on client needs demonstrates a commitment to regulatory flexibility. By collaborating with technicians to adjust purity or physical characteristics, manufacturers can ensure their bare supplements perfectly match the legal and technical requirements of different regional pharmacopeias.
Future Trends in Pharmaceutical Intermediates
The industry is moving toward "green chemistry," where the synthesis of intermediates like 6-Chloro-1,3-dimethyluracil is optimized to reduce waste and energy consumption. Innovations in catalytic processes are expected to increase yields while reducing the environmental footprint of chemical manufacturing.
Digital transformation is also playing a role, with AI-driven supply chain management reducing lead times from the standard 10 days to even faster windows. Real-time tracking of shipments from Chinese ports ensures that just-in-time manufacturing is possible for global pharmaceutical plants.
As personalized medicine grows, the demand for smaller, high-purity batches of intermediates will increase. The flexibility to provide MOQs as low as 1kg allows researchers to innovate with new drug derivatives without the burden of excessive inventory.
Analysis of 6-Chloro-1,3-dimethyluracil Market Application Dimensions
| Application Target |
Key Intermediate Role |
Critical Purity Level |
Regulatory Standard |
| Urapidil Synthesis |
Core Structural Base |
≥ 98% |
CAS 6972-27-6 |
| Nifekalant Production |
Precursor Molecule |
≥ 98% |
EINECS 230-205-2 |
| Hypertension Treatment |
BP Lowering Precursor |
High Grade |
Pharmacopeia Compliant |
| Antiarrhythmic Drugs |
Active Site Component |
Analytical Grade |
MSDS Verified |
| Renal Hypertension |
Therapeutic Intermediate |
≥ 98% |
ISO Certified |
| Custom API Research |
R&D Building Block |
Customizable |
Client-Specific Spec |
FAQS
It serves as a critical intermediate for synthesizing Urapidil, used for treating blood pressure and heart failure, and Nifekalant, an antiarrhythmic drug. Its high purity ensures the stability and efficacy of these final pharmaceutical products.
Yes, free samples are available for testing to ensure the material meets your specific requirements. The customer is only responsible for the delivery cost, allowing for a risk-free quality verification before committing to larger volumes.
The product is packaged in 25kg bags. For large-scale international shipping, a standard 20FCL container can load 12 metric tons with pallets, ensuring secure transport from China's main ports to your facility.
We provide TDS and MSDS for every batch and welcome third-party inspections. If you have a specific spec, our technicians can check for compatibility or customize the product to ensure it meets your exact needs.
Our standard delivery lead time is within 10 days after receiving payment. This efficiency is supported by our strong factory partnerships and streamlined logistics network across China.
We accept a wide range of payment terms including L/C, T/T, Western Union, MoneyGram, and Paypal, depending on the country of the buyer to ensure a smooth and secure financial transaction.
Conclusion
6-Chloro-1,3-dimethyluracil stands as a cornerstone intermediate in the production of vital cardiovascular medications. By maintaining a purity of 98% and adhering to strict CAS and EINECS standards, it enables the synthesis of Urapidil and Nifekalant, directly contributing to the global treatment of hypertension and cardiac arrhythmias. The synergy of high-quality chemical production, transparent documentation, and efficient logistics ensures that pharmaceutical manufacturers can produce life-saving drugs with total confidence.
Looking forward, the integration of green chemistry and digital supply chain optimization will further enhance the accessibility and sustainability of these critical intermediates. For companies seeking reliable, high-purity chemical precursors to support their API development, partnering with experienced suppliers is the key to long-term success and patient safety. Visit our website for more information: www.kxdchem.com
