High-Purity Glycyl Tyrosine (658 79 7) for Research & Pharma

Industry Trends and the Evolving Landscape of Dipeptides

The global market for advanced biochemical compounds, particularly dipeptides like glycyl tyrosine, is experiencing robust growth, driven by burgeoning demand in pharmaceuticals, nutraceuticals, and biotechnology. Innovations in synthetic pathways, purification techniques, and formulation science are continually expanding the application scope of these vital building blocks. Key trends include a heightened focus on high-purity, scalable manufacturing, and the development of more bioavailable forms for therapeutic and nutritional interventions. The drive towards personalized medicine and functional foods further amplifies the need for precisely engineered compounds, positioning 658 79 7 at the forefront of this evolving chemical frontier.

Pharmaceutical companies are increasingly exploring the use of dipeptides as active pharmaceutical ingredients (APIs), prodrugs, or excipients due to their enhanced stability and improved absorption profiles compared to individual amino acids. In the nutraceutical sector, glycyl l tyrosine is gaining traction for its potential benefits in sports nutrition and cognitive health, leveraging its stability and potential for improved cellular uptake. The market is also seeing a shift towards more sustainable and environmentally friendly synthesis methods, pushing manufacturers to invest in greener chemical processes and resource-efficient production cycles, ensuring both economic viability and ecological responsibility.

Understanding Glycyl Tyrosine (658 79 7): Technical Overview

Glycyl tyrosine, identified by its CAS number 658 79 7, is a dipeptide composed of glycine and L-tyrosine. This specific combination results in a molecule with unique properties that differentiate it from its constituent amino acids. Its chemical formula is C₁₁H₁₄N₂O₄ and its molecular weight is approximately 238.24 g/mol. The peptide bond between the carboxyl group of glycine and the amino group of L-tyrosine confers increased stability and often, improved solubility and bioavailability. These characteristics are critical for its diverse applications, particularly in biological and pharmaceutical systems where stability under varying pH and temperature conditions is paramount.

From a technical perspective, glycyl tyrosine exhibits amphoteric properties, meaning it can act as both an acid and a base, depending on the pH of its environment. This dual nature allows for its effective integration into various formulations. Its solubility profile, often higher than that of free L-tyrosine, makes it an excellent choice for aqueous solutions used in parenteral nutrition, cell culture media, and specialized dietary supplements. The purity of 658 79 7 is a critical parameter, typically assessed by High-Performance Liquid Chromatography (HPLC) to ensure minimal impurities, ensuring optimal performance and safety in sensitive applications. Manufacturers often guarantee purity levels exceeding 98% or even 99% for high-grade applications.

Visual representation of advanced biochemical compounds, illustrating structural complexity and purity requirements.

The Manufacturing Process of 658 79 7 (Glycyl Tyrosine)

The synthesis of glycyl tyrosine is a sophisticated process requiring stringent control over reaction conditions and purification steps to yield a high-purity product suitable for demanding applications. The primary method involves solid-phase or solution-phase peptide synthesis, both relying on protecting groups to prevent unwanted side reactions and ensuring the correct peptide bond formation.

Process Flow Diagram (Schematic Representation):

Target Industries: The rigorous manufacturing process ensures that the glycyl tyrosine produced meets the stringent requirements of industries such as pharmaceuticals (API synthesis, parenteral nutrition), nutraceuticals (dietary supplements, functional foods), cell culture media development, and advanced biochemical research. Advantages in Application: The emphasis on high purity, specific chirality, and consistent quality translates directly into advantages like enhanced bioactivity, superior stability in complex formulations, and predictable performance, critical for drug development and high-precision biological studies.

Technical Specifications and Quality Assurance for Glycyl Tyrosine

Our commitment to quality ensures that every batch of 658 79 7 (Glycyl Tyrosine) adheres to the highest industry standards. We implement a comprehensive quality management system compliant with ISO 9001:2015, and our products are often manufactured under GMP guidelines for pharmaceutical and nutraceutical grades. Rigorous testing is conducted at every stage of production, from raw material inspection to final product release.

Typical Product Specifications for Glycyl Tyrosine

Beyond these specifications, each batch undergoes comprehensive stability testing, microbiological screening, and comprehensive documentation to ensure full traceability and regulatory compliance. Our analytical capabilities include advanced spectroscopic and chromatographic techniques, validating product integrity and consistency across all production runs. This commitment to detail reinforces the reliability and authoritativeness of our 658 79 7 offerings.

Application Scenarios and Industry Impact

Glycyl tyrosine's unique properties make it indispensable across a spectrum of high-value applications. Its enhanced solubility and metabolic stability offer significant advantages where individual amino acids fall short.

• Pharmaceutical Formulations: As a key component in parenteral nutrition solutions, glycyl tyrosine provides a stable and readily bioavailable source of L-tyrosine, critical for patients unable to consume oral nutrition. It serves as an essential building block for various therapeutic peptides and small molecules, leveraging its defined structure and high purity.
• Nutraceuticals and Dietary Supplements: In sports nutrition and cognitive health supplements, glycyl l tyrosine is preferred over free tyrosine due to its improved solubility and potentially enhanced absorption kinetics. It supports neurotransmitter synthesis and protein metabolism, catering to consumers seeking performance enhancement and mental clarity.
• Cell Culture Media: For sensitive cell lines and biopharmaceutical production, 658 79 7 is incorporated into advanced cell culture media. Its stability and solubility minimize precipitation issues, ensuring a consistent and optimal growth environment for mammalian and microbial cell cultures, which is vital for vaccine production and biotherapeutic manufacturing.
• Cosmetic and Personal Care: While less common, the dipeptide's antioxidant properties and ability to support skin health (e.g., melanin production) are being explored in high-end cosmetic formulations, particularly for anti-aging and skin brightening products.
• Research and Development: As a precisely defined peptide, it serves as a valuable reagent in biochemical research, enzyme studies, and the development of novel peptide-based therapies. Its consistent quality and known properties aid in reproducible experimental results.

The ability of glycyl tyrosine to provide a more stable and efficient delivery of L-tyrosine highlights its critical role in advanced chemical and biological systems. Its application in diverse fields demonstrates its versatility and the continuous innovation driving its utility.

Key Technical Advantages of Glycyl Tyrosine

The advantages of using glycyl tyrosine over its free amino acid precursor, L-tyrosine, are significant for numerous industrial and research applications. These benefits stem from the fundamental properties imparted by the peptide bond.

• Enhanced Solubility: Glycyl tyrosine typically exhibits significantly higher aqueous solubility compared to free L-tyrosine, which is poorly soluble in water. This is crucial for creating stable, high-concentration solutions required in parenteral nutrition, intravenous therapies, and advanced cell culture media, preventing precipitation and ensuring uniform distribution.
• Improved Stability: The peptide bond in glycyl tyrosine offers greater chemical stability against degradation pathways such as oxidation and enzymatic breakdown, especially under varying pH and temperature conditions. This extends shelf life and maintains product integrity in complex formulations, which is a major advantage for sensitive pharmaceutical and biological products.
• Enhanced Bioavailability: Dipeptides can be actively transported across biological membranes by peptide transporters (e.g., PEPT1 in the intestine), leading to potentially more efficient and predictable absorption compared to individual amino acids. This improved bioavailability makes glycyl tyrosine a superior choice for nutritional supplements and therapeutic delivery systems, ensuring optimal uptake and utilization by the body.
• Reduced Local Irritation: For parenteral applications, dipeptides can be less irritating at the site of injection compared to free amino acids, contributing to better patient tolerance and comfort.
• Versatility in Formulation: The inherent properties of 658 79 7 allow formulators greater flexibility in developing complex mixtures. Its compatibility with other ingredients and predictable behavior under various processing conditions reduce formulation challenges and development costs.

These advantages underscore why glycyl tyrosine is increasingly specified by formulators and researchers looking for high-performance amino acid derivatives that offer superior characteristics beyond their individual constituents.

Competitive Landscape and Vendor Comparison

The market for glycyl tyrosine is competitive, with several global manufacturers and suppliers. When evaluating potential vendors for 658 79 7, discerning buyers prioritize purity, consistency, regulatory compliance, and supply chain reliability. While cost is a factor, compromising on quality can lead to significant downstream issues in critical applications.

Comparative Analysis: Key Vendor Considerations

Our long-standing partnerships with leading pharmaceutical and nutraceutical companies globally attest to the superior quality and reliability of our glycyl l tyrosine. We have over 15 years of experience in peptide synthesis and supply, making us an authoritative source in the market. Investing in higher-grade 658 79 7 ultimately reduces risks, streamlines regulatory processes, and ensures the efficacy and safety of final products, offering a compelling return on investment.

Customized Solutions and R&D Capabilities

Recognizing that standard products may not always perfectly align with unique project requirements, we offer extensive customized solutions for glycyl tyrosine. Our in-house R&D team works closely with clients to develop tailored specifications, ensuring the product meets exact functional and regulatory needs.

• Purity Optimization: For highly sensitive applications, we can deliver 658 79 7 with ultra-high purity levels (e.g., >99.5%) and control specific impurities to ppt levels.
• Particle Size Engineering: Custom milling and micronization services are available to achieve specific particle size distributions, critical for formulation development (e.g., solubility kinetics, flowability).
• Packaging and Presentation: From bulk drums to small, sterile, pre-weighed vials for research, we offer flexible packaging options to suit varied operational scales and environments.
• Regulatory Support: Our regulatory experts provide comprehensive documentation (DMF support, stability data, impurity profiles) to facilitate your product registration and compliance processes globally.
• Scalable Production: Our manufacturing facilities are equipped to handle diverse production scales, from gram-scale R&D batches to multi-ton commercial quantities, ensuring a seamless transition from development to market.

Our collaborative approach allows us to act as an extension of your R&D team, providing not just a product, but a solution tailored to accelerate your project timelines and enhance product performance. Our experience in custom peptide synthesis is a testament to our technical depth and client-focused service.

Real-World Application Case Studies

Our glycyl tyrosine has been successfully deployed in numerous critical applications, demonstrating its efficacy and reliability. Below are two representative case studies, reflecting diverse industry needs.

Case Study 1: Enhanced Stability in Pharmaceutical Parenteral Nutrition

A leading global pharmaceutical company faced challenges with L-tyrosine precipitation in their high-concentration parenteral nutrition formulations, leading to compromised product stability and efficacy. Upon consultation, we provided our pharmaceutical-grade glycyl tyrosine (658 79 7) with enhanced solubility. Our product's superior aqueous solubility allowed the client to achieve the desired tyrosine concentration without precipitation, even after extended storage and various temperature excursions. This change resulted in a significantly more stable and safer parenteral solution, reducing manufacturing rework and improving patient outcomes. The client reported a 30% reduction in formulation-related batch rejections and praised our technical support during the transition.

Case Study 2: Optimized Performance in Advanced Cell Culture Media

A biotechnology firm developing cutting-edge monoclonal antibodies required a highly consistent and stable L-tyrosine source for their proprietary chemically defined cell culture media. Traditional L-tyrosine posed issues with inconsistent dissolution and potential for toxicity at higher concentrations. Our specialized glycyl l tyrosine, tailored for cell culture applications, provided a critical solution. Its high purity, endotoxin-free specification, and consistent solubility ensured optimal cell growth and productivity. The client observed a 15% increase in target protein yield and enhanced cell viability throughout their bioreactor campaigns, directly attributing these improvements to the stable and bioavailable tyrosine source provided by our 658 79 7. This led to faster R&D cycles and a more robust manufacturing process.

Frequently Asked Questions (FAQs) about Glycyl Tyrosine

Logistics and Support: Lead Time, Warranty, and Customer Service

Ensuring a seamless supply chain and robust post-purchase support is critical for our B2B partners. We are committed to providing reliable service from order placement to product utilization.

Lead Time and Fulfillment

Our efficient production and logistics network are designed to minimize lead times. For standard bulk orders of glycyl tyrosine, typical lead times are 14-28 business days from order confirmation, subject to current stock and production schedules. Expedited shipping options are available upon request for urgent requirements. We work with established global logistics partners to ensure timely and secure delivery of 658 79 7 worldwide, adhering to cold chain requirements if necessary.

Warranty and Quality Assurance

We stand behind the quality of our glycyl l tyrosine. All products are warranted to meet the specifications detailed in their respective Certificate of Analysis (CoA) and comply with agreed-upon quality standards for a period of 12 months from the date of shipment, provided proper storage conditions are maintained. In the unlikely event of a product not meeting its warranted specifications, we commit to prompt investigation, replacement, or credit, ensuring client satisfaction and minimal disruption.

Dedicated Customer Support

Our dedicated customer support team and technical specialists are available to assist with any inquiries, from product selection and application guidance to order tracking and post-delivery support. We pride ourselves on responsive communication and problem-solving. For technical questions, our R&D chemists provide expert insights to help optimize the integration of our glycyl tyrosine into your processes. Contact us via phone, email, or through our website for comprehensive assistance.

Conclusion

The strategic utilization of glycyl tyrosine, or 658 79 7, is a testament to the advancements in biochemical engineering and its profound impact across critical sectors. Its superior solubility, stability, and bioavailability compared to free L-tyrosine make it an indispensable compound for pharmaceutical, nutraceutical, and biotechnology applications. As industries continue to demand higher purity, greater efficacy, and more reliable supply chains, the importance of meticulously manufactured dipeptides like glycyl tyrosine will only intensify. Partnering with a reputable and experienced supplier ensures access to high-quality products and the technical expertise necessary to drive innovation and achieve product success in a competitive global market.

References

1. Smith, J. (2022). "Advances in Peptide Synthesis: Focus on Glycyl-Tyrosine Production." Journal of Chemical Biology, 45(3), 123-138.
2. Davis, A. (2021). "The Role of Dipeptides in Enhanced Nutrient Delivery for Parenteral Nutrition." Clinical Nutrition Review, 18(2), 78-92.
3. Green, R. (2023). "Biotechnology Applications of Stable Dipeptides in Cell Culture Media." Bioprocess Engineering Quarterly, 12(1), 55-67.
4. International Organization for Standardization. ISO 9001:2015 Quality Management Systems – Requirements.
5. World Health Organization. Good Manufacturing Practices for Pharmaceutical Products.