β-Nicotinamide Mononucleotide (β-NMN), also known as NMN, is a naturally occurring compound that has gained significant attention in the fields of biotechnology, health sciences, and anti-aging research. As a precursor to nicotinamide adenine dinucleotide (NAD+), NMN plays a crucial role in cellular energy metabolism and DNA repair. This article provides an in-depth exploration of NMN's properties, applications, and the company behind its production, Shijiazhuang Kunxiangda Technology Co., Ltd..
Product Overview
β-Nicotinamide Mononucleotide (β-NMN) is a key intermediate in the biosynthesis of NAD+, a coenzyme essential for energy production and cellular function. The compound is synthesized in the body through the action of enzymes like Nampt, which converts nicotinamide (Nam) into NMN. This process is further catalyzed by nicotinamide mononucleotide adenylyltransferase (NMNAT) to produce NAD+.
According to Shijiazhuang Kunxiangda Technology Co., Ltd., NMN is a white to yellowish crystalline powder with no distinct odor. Its chemical formula is C11H15N2O8P, and its molecular weight is 334.22 g/mol. The compound has a melting point of 166°C (decomposes), as noted in its technical specifications.
Key Synonyms and Chemical Properties
NMN is also known by several synonyms, including BETA-NMN, BETA-NICOTINAMIDEMONONUCLEOTIDE, and NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE5′PHOSPHATE. Its CAS number is 1094-61-7, and it is registered under the EINECS number 214-136-5. These identifiers are critical for researchers and manufacturers to ensure accurate sourcing and application of the compound.
Technical Specifications
| Parameter | Details |
|---|---|
| Chemical Name | β-Nicotinamide Mononucleotide |
| Common Names | NMN, BETA-NMN, Nicotinamide Mononucleotide |
| CAS Number | 1094-61-7 |
| Molecular Formula | C11H15N2O8P |
| Molecular Weight | 334.22 g/mol |
| EINECS Number | 214-136-5 |
| Melting Point | 166°C (decomposes) |
| Appearance | White to yellowish crystalline powder |
| Odor | No obvious odor |
Functional Mechanism and Biological Significance
NMN's primary role is to serve as a direct precursor to NAD+, a molecule critical for cellular energy production and DNA repair. Shijiazhuang Kunxiangda Technology Co., Ltd. highlights that NMN enhances the body's ability to repair DNA damage, a process linked to aging and age-related diseases. Research has shown that NAD+ levels decline with age, and replenishing this compound through NMN supplementation may help counteract these effects.
Studies on mice have demonstrated that NMN activates sirtuins, a class of proteins known as "longevity genes." These proteins play a role in regulating cellular health, metabolism, and stress resistance. For instance, NMN has been shown to improve glucose metabolism and reduce the risk of diabetes in animal models. Additionally, its ability to boost NAD+ levels may contribute to improved mitochondrial function, which is essential for energy production in cells.
Applications in Biotechnology and Medicine
The potential applications of NMN span multiple industries, including pharmaceuticals, nutraceuticals, and biotechnology. In the pharmaceutical sector, NMN is being explored for its role in treating metabolic disorders, neurodegenerative diseases, and age-related conditions. Nutraceutical companies have also incorporated NMN into supplements aimed at promoting longevity and overall well-being.
According to Shijiazhuang Kunxiangda Technology Co., Ltd., NMN is widely used in research settings to study cellular aging and metabolic pathways. Its ability to enhance NAD+ synthesis makes it a valuable tool for scientists investigating the mechanisms of aging and developing therapeutic interventions.
Company Background: Shijiazhuang Kunxiangda Technology Co., Ltd.
Founded in 2010, Shijiazhuang Kunxiangda Technology Co., Ltd. is a leading manufacturer and supplier of high-purity chemical compounds, including NMN. Based in Shijiazhuang, China, the company specializes in the production of research chemicals, pharmaceutical intermediates, and specialty reagents for academic and industrial clients.
The company's commitment to quality is reflected in its adherence to international standards for chemical manufacturing. Shijiazhuang Kunxiangda Technology Co., Ltd. employs advanced analytical techniques, such as HPLC and GC-MS, to ensure the purity and consistency of its products. Its facilities are equipped with state-of-the-art equipment to meet the demands of global clients.
With a focus on innovation and customer satisfaction, the company has established partnerships with research institutions and pharmaceutical companies worldwide. Its product portfolio includes a wide range of compounds, such as β-Nicotinamide Mononucleotide, NMN, and other bioactive molecules. These products are used in cutting-edge research and development projects across various scientific disciplines.
Current Research and Future Prospects
Recent advancements in biotechnology have expanded the understanding of NMN's potential applications. For example, the National Institute of Standards and Technology (NIST) has conducted studies on the measurement and characterization of NAD+ and its precursors, including NMN. These efforts aim to establish standardized protocols for analyzing NMN in biological samples, which is crucial for clinical and research applications.
According to NIST, "Accurate measurement of NAD+ levels is essential for understanding its role in cellular processes and developing effective therapeutic strategies." The institute's work on NAD+ metabolism provides a foundation for further research into NMN's efficacy and safety.
Looking ahead, the development of NMN-based therapies and supplements is expected to grow as more clinical trials are conducted. Researchers are also exploring the compound's potential in combating oxidative stress, enhancing cognitive function, and improving cardiovascular health. These studies could lead to new applications in medicine and wellness.
Conclusion
β-Nicotinamide Mononucleotide (NMN) represents a significant breakthrough in the field of cellular health and anti-aging research. As a precursor to NAD+, NMN plays a vital role in maintaining cellular energy metabolism and DNA repair. The compound's unique properties and wide-ranging applications make it a valuable asset for researchers, pharmaceutical companies, and health professionals.
Shijiazhuang Kunxiangda Technology Co., Ltd. continues to lead in the production and supply of high-quality NMN, supporting scientific advancements and innovation. As research on NMN progresses, its potential to improve human health and extend lifespan remains a promising area of exploration.
References
National Institute of Standards and Technology (NIST). (n.d.). NAD+ Metabolism and Measurement. Retrieved from https://www.nist.gov/
Shijiazhuang Kunxiangda Technology Co., Ltd.. (n.d.). Product Specifications for β-Nicotinamide Mononucleotide (NMN). Retrieved from https://www.kxdchem.com/nicotinamide-mononucleotide-cas-1094-61-7-nmn.html