While the general pattern favors morning supplementation, trustworthiness in consumption advice also recognizes individual variability. Health practitioners advocate for customization of any supplement regime, urging users to monitor personal responses to different timing. For some, splitting the dose between morning and evening could optimize absorption and personal benefit, particularly for those with specific sleep patterns or energy needs. If sleep disturbances emerge when taking PQQ in the evening, adjusting the timing to the morning can be beneficial. Conversely, if sustained energy throughout the day is a goal, a second dose post-lunch might be trialed to find the perfect balance. Consulting with a healthcare professional can provide additional insight tailored to one’s unique physiology and lifestyle, further enhancing the effective use of PQQ. Conclusively, the effective use of PQQ extends beyond its timing to include considerations of dose and duration. Beginners often start with a conservative dose of around 10-20 mg per day, escalating gradually as required and under professional guidance. Regular long-term use may be necessary to witness profound benefits, particularly in areas like joint health or cognitive longevity. Informed by real experiences, scientific understanding, and professional insights, determining when to take PQQ involves evaluating personal health objectives and daily routines. Fundamental to unlocking its potential is a consistent and personalized approach, bolstered by professional consultation and a mindful observation of one’s own body responses.