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Pentoxifylline, commonly known by its brand name Trental, is a pharmaceutical agent belonging to a class of drugs known as methylxanthines. It is primarily used to improve blood flow in patients with peripheral vascular disease, often presenting symptoms such as leg pain or cramping during physical activities, known medically as claudication. This article aims to provide insights into the drug, its mechanism of action, benefits, possible side effects, and clinical applications.


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The mechanism of action of pentoxifylline is multifaceted. Primarily, it acts as a phosphodiesterase inhibitor, leading to an increase in intracellular cyclic AMP levels. This, in turn, causes vasodilation, thereby improving blood flow to tissues. Additionally, pentoxifylline reduces blood viscosity by decreasing red blood cell aggregation and improving their deformability. These properties are especially beneficial for patients suffering from peripheral artery disease, diabetic ulcers, and chronic venous insufficiency.


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1. Peripheral Arterial Disease (PAD) This is a common circulatory problem in which narrowed arteries reduce blood flow to the limbs, leading to symptoms like cramping or pain during physical activity.

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