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From a metabolic perspective, alpha-keto leucine calcium may also play a role in maintaining healthy blood glucose levels. Research indicates that alpha-keto acids can influence insulin sensitivity and help regulate blood sugar. This is particularly beneficial for individuals aiming to manage their body composition or those with metabolic concerns. The integration of calcium can further support metabolic health by facilitating various enzymatic reactions involved in carbohydrate and fat metabolism.


Platelet aggregation refers to the clumping together of platelets in the blood, a process crucial for hemostasis, or the cessation of bleeding. However, when platelets aggregate excessively, it can result in the formation of blood clots, obstructing the smooth flow of blood through the vessels. Such obstructions pose a significant risk, potentially leading to conditions like heart attacks, strokes, or pulmonary embolisms.

Additionally, PQQ has been linked to cognitive function and brain health. Some studies have suggested that PQQ may enhance memory and learning capabilities by reducing neurodegeneration and promoting neuronal growth. The compound appears to influence brain-derived neurotrophic factor (BDNF), a protein that plays a vital role in the survival and growth of neurons. Enhanced BDNF levels can lead to improved brain function and potentially protect against age-related cognitive decline.


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In drinking water treatment, cationic polymers are often used in combination with coagulants, such as aluminum and iron salts, to enhance the removal of turbidity and microorganisms. These polymers improve the efficiency of the coagulation-flocculation process, leading to clearer water with reduced pathogen levels. Moreover, the use of cationic polymers can also reduce the amount of chemical coagulants required, which is beneficial for both environmental and economic reasons.


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  • After oral ingestion, the absorption of titanium dioxide particles is low, however they can accumulate in the body, Maged Younes, chair of the European Food Safety Authority's expert Panel on Food Additives and Flavourings, said in a May 2021 statement.

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  • lithopone supplier 30% is the perfect solution for partial substitution of TiO2 in fillers due to its very soft nature and hardly any shrinkage properties. 

  • In an early study Jani et al. administred rutile TiO2 (500 nm) as a 0.1 ml of 2.5 % w/v suspension (12.5 mg/kg BW) to female Sprague Dawley rats, by oral gavage daily for 10 days and detected presence of particles in all the major gut associated lymphoid tissue as well as in distant organs such as the liver, spleen, lung and peritoneal tissue, but not in heart and kidney. The distribution and toxicity of nano- (25 nm, 80 nm) and submicron-sized (155 nm) TiO2 particles were evaluated in mice administered a large, single, oral dosing (5 g/kg BW) by gavage. In the animals that were sacrificed two weeks later, ICP-MS analysis showed that the particles were retained mainly in liver, spleen, kidney, and lung tissues, indicating that they can be transported to other tissues and organs after uptake by the gastrointestinal tract. Interestingly, although an extremely high dose was administrated, no acute toxicity was observed. In groups exposed to 80 nm and 155 nm particles, histopathological changes were observed in the liver, kidney and in the brain. The biochemical serum parameters also indicated liver, kidney and cardiovascular damage and were higher in mice treated with nano-sized (25 or 80 nm) TiO2 compared to submicron-sized (155 nm) TiO2. However, the main weaknesses of this study are the use of extremely high single dose and insufficient characterisation of the particles.

  • Are your suppliers aware of this ban? Are they sourcing alternatives to comply with the legislative requirements?
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  • Lithopone

  • Overwhelmingly, research that’s relevant to human eating patterns shows us that E171 is safe when ingested normally through foods and drugs (1,2).

  • Safety Concerns and Regulations
  • A legal additive in the United States, titanium dioxide is used in everything from food to consumer goods and the U.S. Food and Drug Administration says regulated use of the product as a color additive in food is safe within certain restrictions.

  • For a substance that is relatively unknown to the public, it’s amazing how many everyday products TiO2 can be found in. Because of its many varied properties, our skin, cities, cars, homes, food and environment are made brighter, safer, more resilient and cleaner by TiO2. With a legacy of 100 years of safe commercial use, TiO2 is only going to become more vital as our environment faces greater challenges from a growing population.

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  • Titanium dioxide is produced in two main forms. The primary form, comprising over 98 percent of total production, is pigment grade titanium dioxide. The pigmentary form makes use of titanium dioxide’s excellent light-scattering properties in applications that require white opacity and brightness.

  • Furthermore, TiO2 is also utilized in food and pharmaceutical industries as a colorant and additive, owing to its inertness and non-reactive nature. However, its use in these sectors is strictly regulated to ensure consumer safety.
  • For the Second Quarter of 2022

  • NIOSH's primary concern with titanium dioxide lies in its use as a pigment in paints, plastics, and other industrial products, where workers may be exposed to airborne particles. TiO2 is generally considered safe when used in its solid form; however, inhalation of fine dust particles can pose respiratory risks. NIOSH conducts rigorous studies to establish recommended exposure limits (RELs) to ensure worker safety.
  • When used as a base or colorant in a product, titanium dioxide becomes handy in formulas meant to offer a lot of brightness and opacity. Titanium dioxide is so pigmented, in fact, that it’s used not only in white and pastel-colored products but also in darker shades, as well.

  • Rutile, also known as titanium oxide (TiO2), is a hard, lustrous, and chemically inert mineral. It is composed of titanium and oxygen atoms and has a tetragonal crystal structure. Rutile is characterized by its high refractive index, high melting point, and excellent electrical conductivity. These properties make it an ideal material for a wide range of applications, including pigments, coatings, plastics, ceramics, and electronics.
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