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- In the pharmaceutical industry, HPMC is used as a binder, disintegrant, and film-forming agent. It is commonly used in the production of tablets, capsules, and oral suspensions. HPMC helps to bind the active ingredients together, ensuring that they are released slowly and consistently in the body. It also helps to improve the disintegration of tablets and capsules, making them easier to swallow.
- Applications of HPMC in Building Coating Adhesives
- HPMC is a chemically modified cellulose derivative that is water-soluble and has a high degree of stability. It is commonly used as a thickening agent, stabilizer, and emulsifier in many products. Its ability to form transparent gels makes it a popular choice in pharmaceuticals for coating tablets and controlling drug release.
- In organic solvents like ethanol, acetone, or isopropyl alcohol, HPMC's solubility is limited. However, a blend of water and these solvents can enhance its solubility, making it useful in applications where a combination of hydrophilic and hydrophobic properties is desired.
- Another area where Ashland's hydroxyethyl cellulose shines is in construction materials such as mortar and concrete. It acts as a water-retaining agent, allowing for better workability and reduced cracking during drying stages. This ultimately leads to stronger and more durable structures.
- In conclusion, the solubility of HPMC in ethanol is a complex phenomenon that is influenced by several factors, including the degree of substitution, molecular weight, and temperature of the solution. By carefully controlling these variables, researchers can tailor the properties of HPMC-based materials to meet the requirements of their specific applications.
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1、What is HPMC?
- HPMC stands for Hydroxypropyl Methylcellulose, a chemical compound widely utilized in various industries due to its unique properties and versatile applications. It is a semi-synthetic polymer derived from cellulose, a natural polymer found abundantly in plant cell walls.
- The 'HPMC%' you might encounter refers to the percentage concentration of HPMC in a particular product. This percentage can vary depending on the intended application and desired effects. Higher percentages typically result in thicker consistency or slower drug release.
Besonderheiten: Wässrige HPMC-Gele neigen dazu, bei der Erwärmung bei einer bestimmten Temperatur sehr schnell ihre Viskosität zu erhöhen. Diese Temperatur wird häufig als Gelpunkt bezeichnet, was in diesem Fall jedoch nicht völlig korrekt ist. Dieser Verfestigungsprozess ist reversibel, das heißt, sobald die Temperatur genügend gefallen ist, wird auch das Gel wieder flüssiger. Diesen Effekt macht man sich z. B. in der Lebensmitteltechnologie zunutze: Bratlingen wird HPMC zugesetzt, damit sie beim Braten (hohe Temperatur) fest, beim Verzehr (niedrigere Temperatur) jedoch wieder zart sind.
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3. Hydroxypropyl Methylcellulose has stability to acids and bases and its aqueous solution is very stable at pH 2-12. Caustic soda and lime water have little impact on its performance. but bases can accelerate its dissolution rate and slightly increase the viscosity. Hydroxypropyl Methylcellulose has the stability to general salts, but the Hydroxypropyl Methylcellulose solution viscosity will tend to increase when the concentration of the salt solution is high.