Coenzyme Q10, or CoQ10, is a naturally occurring antioxidant found in every cell of the body. It is vital for the production of adenosine triphosphate (ATP), the primary energy carrier in cells. Like PQQ, CoQ10 is involved in mitochondrial function, providing energy necessary for cellular activities. The body's levels of CoQ10 can decrease with age, certain medical conditions, and the use of specific medications, particularly statins.
One of the primary rationales for chlorination is its role in preventing outbreaks of waterborne illnesses. Diseases such as cholera, giardiasis, and typhoid fever are typically transmitted through contaminated water. The introduction of chlorination in municipal water systems drastically reduced the incidence of these diseases in the 20th century, contributing to improved public health and life expectancy.
Once the drug candidate has shown promise, the next step is process development. Here, chemists focus on creating a scalable synthesis pathway for the API. This involves optimizing reaction conditions, selecting appropriate reagents and solvents, and determining the most efficient methodology for ensuring a high yield of the active ingredient. During this stage, companies also consider the environmental impact of their processes and the feasibility of producing the API on a larger scale.