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In conclusion, the half-life of PQQ is an essential consideration for anyone interested in harnessing its health benefits. With a range of 3 to 20 hours, the pharmacokinetics of PQQ suggests a need for regular supplementation to maintain effective levels in the body. As research continues to evolve, a deeper understanding of how PQQ interacts with other compounds, along with the variability of metabolic responses, will pave the way for more tailored and effective health strategies. Ultimately, whether one is seeking cognitive enhancement or metabolic support, recognizing the significance of PQQ's half-life can lead to more informed decisions regarding supplementation.