Once an API has demonstrated its potential through clinical trials, pharmaceutical companies must then ensure that it can be manufactured at scale without compromising its quality. This step often involves the establishment of Good Manufacturing Practices (GMP), which dictate the standards for the production of APIs to guarantee that they meet the necessary quality parameters.
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Despite its advantages, chlorination does present some challenges and concerns. The reaction of chlorine with organic matter in water can produce by-products known as trihalomethanes (THMs) and haloacetic acids (HAAs), which are classified as potential carcinogens. To mitigate these risks, water treatment plants often conduct regular monitoring of chlorine by-products to ensure they remain within acceptable limits set by health authorities.
While PQQ is available as a dietary supplement, it can also be obtained from various food sources. Foods such as green peppers, kiwi fruit, and fermented soy products like natto are known to be rich in PQQ. For those considering supplementation, it's essential to consult with a healthcare provider, as the appropriate dosage can vary based on individual health needs and conditions.