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The development process begins with drug discovery, focusing on identifying potential candidates that can effectively target specific biological pathways. During this phase, researchers explore various chemical entities to assess their activity against disease models. Once promising candidates emerge, they advance into preclinical studies, where APIs undergo rigorous testing for pharmacokinetics, pharmacodynamics, and toxicity. These studies ensure that selected APIs have the potential for success in clinical trials.


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Penicillin, a pioneer among antibiotics, once had a production process that caused significant environmental pollution. In recent years, with the application of eco-friendly pharma intermediates, penicillin production has become cleaner and more efficient. For instance, using biocatalysis instead of chemical catalysis not only increases penicillin yield but also significantly reduces wastewater and gas emissions, achieving green production processes. Additionally, optimizing fermentation techniques has improved the biosynthesis efficiency of penicillin, reduced chemical synthesis steps, and lowered energy and resource consumption.

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Pyrroloquinoline Quinone is a relatively newer entrant in the world of nutritional supplements. Like CoQ10, PQQ possesses antioxidant properties but also offers unique benefits. Research indicates that PQQ can stimulate the production of new mitochondria, a process known as mitochondrial biogenesis. This is vital because mitochondria are the powerhouses of our cells, and increasing their number can lead to improved energy metabolism and enhanced cellular function.


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Despite its advantages, the use of PTSA in water treatment is not without challenges. Its production and handling require careful consideration due to its corrosive nature. Additionally, there is a need for more research to fully understand the long-term effects of PTSA on the environment and aquatic ecosystems.


3. Biocides To control microbial growth, various biocides are introduced into the cooling water. These can be chlorine-based, bromine-based, or non-oxidizing biocides. Proper use of biocides is crucial to prevent the proliferation of harmful bacteria and algae, which can lead to biofouling.


 

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