definition of api in pharma

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Peripheral Vascular Disease (PVD): Pentoxifylline is commonly prescribed for individuals suffering from peripheral vascular disease, a condition characterized by narrowing or blockage of blood vessels in the arms, legs, or other peripheral areas of the body. By improving blood flow and circulation to affected limbs, pentoxifylline helps alleviate symptoms such as pain, cramping, and numbness, thereby enhancing the overall quality of life for patients with PVD.

The mechanism of action of pentoxifylline is multifaceted. Primarily, it acts as a phosphodiesterase inhibitor, leading to an increase in intracellular cyclic AMP levels. This, in turn, causes vasodilation, thereby improving blood flow to tissues. Additionally, pentoxifylline reduces blood viscosity by decreasing red blood cell aggregation and improving their deformability. These properties are especially beneficial for patients suffering from peripheral artery disease, diabetic ulcers, and chronic venous insufficiency.


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