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While pentoxifylline is not the first-line treatment for IC—where supervised exercise therapy and lifestyle modifications are typically recommended—its role becomes important for patients who are not candidates for surgery or those who continue to experience symptoms despite these primary interventions. Additionally, it may be used alongside other medications like cilostazol, which has been shown to enhance walking distance further.


2. Diabetic Ulcers For patients with diabetes, pentoxifylline has shown promise in promoting healing of chronic ulcers, particularly those located on the feet. Improved circulation aids in the delivery of nutrients essential for wound healing.


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Another aspect to consider is the potential for accumulation and long-term use. Although the short half-life suggests that PQQ does not linger in the body for extended periods, regular supplementation can lead to sustained benefits, especially in mitochondrial biogenesis and neuroprotection. Some studies suggest that continued use of PQQ can have cumulative effects, enhancing its ability to support cognitive function and overall health over time.


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1. Peripheral Arterial Disease (PAD) Patients suffering from PAD often experience pain in their legs due to inadequate blood flow. Pentoxifylline can improve walking distance and reduce the cramping pain associated with this condition.


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