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4. Headaches A few users have noted an increase in headache frequency or intensity while taking PQQ. This could be related to the compound's impact on neurotransmitter levels or blood circulation.


Pentoxifylline is a methylxanthine derivative that has been widely used in the medical field since its introduction in the late 20th century. Its primary mechanism of action involves the improvement of blood flow by reducing the viscosity of blood, which enhances the flexibility of red blood cells. This unique property allows it to be effective in various clinical applications, particularly in the treatment of circulatory disorders.


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Once a viable API is developed, extensive clinical trials are conducted to evaluate its safety and efficacy in humans. Regulatory bodies, such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), require comprehensive data on the API before granting approval for the drug's market release. These regulatory frameworks ensure that only safe and effective medicines reach patients.


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