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CoQ10 is a naturally occurring antioxidant found in the body, primarily in the mitochondria, where it plays a critical role in the production of ATP (adenosine triphosphate), the energy currency of the cell. Like PQQ, CoQ10 levels tend to decline with age, which can lead to decreased energy production and increased susceptibility to oxidative damage.
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In addition to its antioxidant capabilities, PQQ has been found to influence mitochondrial biogenesis, a process through which new mitochondria are formed to meet the energy demands of the cell. For instance, research has demonstrated that PQQ can stimulate the expression of proteins involved in mitochondrial biogenesis, such as PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha). This activation is crucial, as an increase in mitochondria within cells correlates with enhanced energy production and improved cellular function, particularly during periods of metabolic stress.
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