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1. Gastrointestinal Distress Some users have reported experiencing upset stomach, nausea, or diarrhea after taking PQQ. This is quite common with many dietary supplements, especially if taken on an empty stomach or in high doses.


Chemical

The combination of PQQ and CoQ10 can amplify their respective benefits. For example, while PQQ promotes mitochondrial biogenesis, CoQ10 enhances the efficiency of ATP production in existing mitochondria. This synergy may provide enhanced energy levels, improved physical performance, and better endurance.


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