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Mitochondria also have their own DNA (mtDNA), which is distinct from the nuclear DNA found in the cell's nucleus. This mitochondrial DNA is inherited maternally and plays a critical role in the organelle's functions. Mutations in mtDNA can lead to various mitochondrial diseases, which can affect multiple systems in the body. Symptoms can range from mild to severe, depending on the type of tissue affected and the nature of the mutation.


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4. Metformin Specified for managing type 2 diabetes, metformin acts by improving insulin sensitivity and decreasing glucose production in the liver. This API is fundamental in helping patients maintain blood sugar levels.


Both API and formulation development face numerous challenges. One significant challenge is the inherent variability in biological systems, which can affect how drugs perform in patients. Additionally, regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) impose rigorous standards that drug developers must meet to ensure product safety and efficacy.


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