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Despite its benefits, isoflurane does have some drawbacks. The most significant concerns include respiratory irritation, which can lead to coughing or breath-holding during induction, and the risk of postoperative nausea and vomiting. Patients with a history of respiratory issues may also experience compounded effects when using isoflurane. Furthermore, while isoflurane is effecive in maintaining anesthesia, it does not provide analgesic properties on its own, necessitating the use of additional medications to manage pain effectively during and after surgery.


Additionally, PQQ has antioxidant properties, helping to combat oxidative stress. Oxidative stress occurs when there is an imbalance between free radicals and antioxidants in the body, leading to cellular damage and inflammation. High levels of oxidative stress have been linked to various diseases, including respiratory illnesses, which are particularly relevant in the case of COVID-19. By reducing oxidative damage, PQQ may contribute to improved respiratory function and overall health.


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