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Once synthesized, intermediates must undergo purification processes, such as crystallization or chromatography, to eliminate impurities and by-products. Quality control is paramount in this industry; every batch of intermediates must be rigorously tested to meet stringent regulatory standards set forth by agencies like the FDA or EMA. This ensures that only high-quality intermediates are used in the production of APIs, safeguarding patient health.


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However, the use of antioxidant additives is not without challenges. One significant concern is the potential leaching of these additives from the plastic matrix, especially in applications involving food packaging or medical devices. To mitigate this risk, researchers are exploring the development of “non-leaching” antioxidants, which can provide protection without migrating out of the polymer matrix.


Corrosion is another major issue in chilled water systems that can lead to equipment damage and unscheduled downtime. The presence of dissolved oxygen, carbon dioxide, and chlorides can exacerbate corrosion processes. To mitigate this risk, corrosion inhibitors, such as nitrites, phosphates, or azoles, are added to the chilled water. These inhibitors form a protective film on the metal surfaces, effectively shielding them from corrosive agents. Implementing a tailored chemical treatment program not only prevents corrosion but can also extend the lifespan of the system components.


chemical treatment for chilled water system

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Additionally, the economic feasibility of treatment methods can be a significant barrier, especially for small and medium-sized enterprises. The costs associated with chemical reagents, equipment, and maintenance can add up, leading to calls for more cost-effective, innovative solutions.


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