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Prof. Matthew Wright, chair of EFSA’s working group on E171, noted: “Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive.”
Titanium dioxide makes products, like toothpaste, white and bright. It's also used in makeup, sunscreen, plastic, and paint. (Photo Credit: iStock/Getty Images)
But in the U.S., titanium dioxide is found all over the grocery shelves. Candy like Skittles, Starbursts, and Jell-O, gum like Trident White peppermint gum and Mentos Freshmint Gum, cake products like Duncan Hines Creamy Vanilla Frosting, and Nabisco Chips Ahoy! cookies are just a few of the myriad food items that contain the additive.
Studies suggest that people are more likely to buy and eat foods that are brighter or more vibrant in color. And titanium dioxide is one way to make that happen. You can find it in food products like candy, coffee creamer, baking and cake decorations, and white sauces.
The leading Chinese TiO2 exporter in value and quantity has been Sichuan Lomon, followed by Henan Billions and Gansu CNNC Huayuan. However, Sichuan Lomon exported a value of titanium dioxide by USD100,000,000 more than the second rank Henan Billions. Henan Billions, on the other hand, exported over USD70,000,000 more TiO2 than Gansu CNNC Huayuan. This demonstrates the huge monopole-like position of the newly merged company Henan Lomon, which can determine the market development for TiO2 in China nearly all alone.
So if you’re worried about titanium dioxide, don’t be! With current research and industry recommendations, titanium dioxide is a safe food additive. And if you want to avoid it, that’s ok too! Just don’t expect certain foods to be so white, smooth, and bright.


Titanium dioxide goes into many industrial and consumer products. It makes paper white and bright, it keeps plastics and rubber soft and flexible, and helps remove harmful emissions from car exhaust, among many other uses. In the drug industry, it's a key ingredient in pill capsules and tablet coatings to keep the medicine inside from being affected by sunlight.
In a 2022 study published in the Journal of Hazardous Materials, scientists wanted to examine the effects of titanium dioxide as a food additive on atherosclerosis in mice. (Atherosclerosis refers to a hardening of the arteries.) Researchers fed mice 40 mg/kg of the food additive every day for 4 months, and found that it not only altered gut microbiota but also led to a significantly increased atherosclerotic lesion area, especially in animals that consumed a high-choline western diet (HCD).
Research supports that applying titanium dioxide to the skin in the form of sunscreens, makeup, and other topical products does not pose any health risks.
FAQ – EFSA 2021 safety assessment of titanium dioxide (E171)

titanium dioxide for coatings suppliers. They work closely with customers to understand their specific needs and requirements, providing guidance on the selection of titanium dioxide grades and the formulation of coatings to achieve optimal results. By leveraging their expertise in coatings and materials science, suppliers of titanium dioxide contribute to the development of innovative coatings solutions that deliver superior performance and durability.

The Sydney Morning Herald reported on the finding of nano particles in our food supply here in Australia, despite no testing every carried out on the safety of these products by our food safety body.
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Lithopone, a white pigment composed of a mixture of barium sulfate and zinc sulfide, is commonly used in the leather industry as a coloring agent
. Leather suppliers around the world rely on lithopone to achieve the desired color and finish on their products.Titanium dioxide has similar uses in non-food products. It is used in sunscreen as effective protection against UVA/UVB rays from the sun, which creates a physical barrier between the sun’s rays and the skin. It’s also used to whiten paint, paper, plastic, ink, rubber, and cosmetics.
How can food businesses comply with this Regulation?
Authors like to thank Sebastián García (LAMARX) for spectra acquisition, Carolina Leimbruguer for her support with TEM images and Yanina Altamirano, Nicolas Jaime and Javier Reparaz for animal care assistance.