Unlocking the Potential of 4857 44 7 in Animal Nutrition & Chemical Engineering Innovations
4857 44 7, officially known as D,L-α-Hydroxymethionine Calcium, represents a new generation of methionine source with proven efficacy in animal feed, food ingredients and specialty chemical manufacturing. As the demand for high-efficiency, eco-friendly feed additives intensifies globally, D,L-α-Hydroxymethionine Calcium—commonly referenced as 4857 44 7 in international chemical registries—has emerged as a pivotal product meeting rigorous ISO and FDA standards. This page offers an authoritative analysis of its industry evolution, technical benchmarks, manufacturing flow, and real-world case studies, equipping you with actionable insights backed by verified data.
I. Market & Industry Trends: Demand for D,L-α-Hydroxymethionine Calcium (4857 44 7)
- Global market value (2023): USD $620 million (IndexBox 2023 Report).
- Projected CAGR (2024-2030): 6.4% (mainly in APAC & South America due to advanced feed & livestock industries).
- Drivers: Antibiotics ban in feed, demand for improved protein synthesis, regenerative farming, compliance to ISO/FAMI-QS/BRC feed safety standards.
- Key industry users: Feed producers, compound food industry, chemical intermediates, aquaculture solutions, animal husbandry innovation centers.
- Major regulatory standards referenced: ISO 9001:2015, FAMI-QS, FDA CFR 21, EC 1831/2003 (additives for animal nutrition).
Did you know? The 4857 44 7 (D,L-α-hydroxymethionine calcium) solution enhances amino acid balance by 7-20% in livestock diets compared to conventional L-Methionine (Source: Feed Science & Technology Journal 2023).
II. Technical Parameters of 4857 44 7 (D,L-α-Hydroxymethionine Calcium)
| Item | Specification | Industry Standard | Test Method |
|---|---|---|---|
| CAS No. | 4857-44-7 | ISO 22110 | - |
| Molecular Formula | C5H11NO4S·Ca | Ph.Eur. 10/EU Regulation | GC-MS |
| Molecular Weight | 205.27 (anhydrous) | ISO/FAMI-QS | N/A |
| Appearance | White crystalline powder | ISO 9001:2015 | Visual/Colorimetry |
| Active Content (as Ca Salt), % | ≥ 80.0% | EU 1831/2003 | Titration |
| Moisture, % | ≤ 1.0% | ISO 6529 | Humidity meter |
| Heavy Metals, mg/kg | < 10 | FDA CFR 21 ISO 17025 |
AAS |
| Loss on drying, % | < 2.0 % | Ph.Eur. 10 | Oven method |
| Granularity (100mesh pass) | ≥ 95% | Company STD | Sieve analysis |
III. D,L-α-Hydroxymethionine Calcium Manufacturing Process (4857 44 7)
Process Overview:
The synthesis of 4857 44 7 involves hydroxy analog derivatization, neutralization, and precision crystallization. Compliance with ISO 9001 and FAMI-QS assures consistent quality output. Detailed steps are below:
The synthesis of 4857 44 7 involves hydroxy analog derivatization, neutralization, and precision crystallization. Compliance with ISO 9001 and FAMI-QS assures consistent quality output. Detailed steps are below:
Raw Material Selection
(DL-methionine, Ca(OH)2)
ISO2001:2015 Audited
→
(DL-methionine, Ca(OH)2)
ISO2001:2015 Audited
Hydroxylation Reaction
Temp-controlled Reactor (65-70°C)
→
Temp-controlled Reactor (65-70°C)
Neutralization
Ca(OH)2 dosing; pH 7.5-8.5
→
Ca(OH)2 dosing; pH 7.5-8.5
Crystallization & Filtration
ISO Class 8 Filtration
→
ISO Class 8 Filtration
Drying & Sieving
Hot Air Dryer, 12h / 55°C
→
Hot Air Dryer, 12h / 55°C
Packing & QC Testing
Automated Weighing, ISO 17025 Lab
Automated Weighing, ISO 17025 Lab
- Raw material traceability All primary ingredients, including 4857 44 7, require supplier verification per ISO 9001:2015 and ANSI/NSF guidelines.
- Automated crystallization In-line process control using CNC-monitored reactors guarantees consistent particle size distribution.
- Quality Assurance Batch monitoring under FDA CFR 21; each lot is tested for active ingredient purity & heavy metals (ISO 17025-compliant).
IV. Material & Technical Advantages of 4857 44 7
- Feed Efficiency: Demonstrated to increase amino acid absorption rates (+22.8%) vs. traditional L-methionine (Source: Animal Feed Science & Technology 2022).
- Longevity: 24-month shelf life under normal storage; high thermal & oxidative stability.
- Safety Standard: Passed EU 1831/2003 and FDA feed additive risk assessment; low heavy metal content verified.
- Eco-responsibility: Up to 23% lower carbon footprint in the supply chain compared to reference products (2023 FeedNavigator report).
- Cost-Benefit: Higher feed conversion rate leads to ROI improvement for large farms.
- Versatility: Effective under a wide range of pH/temperature conditions for multi-species breeding/farming.
V. Supplier Comparison Table (Global Key Producers of 4857 44 7)
| Company | Country | Certifications | Batch Consistency | Average Price/MT | Delivery Lead Time |
|---|---|---|---|---|---|
| KXD Chem | China | ISO 9001, FAMI-QS, FDA | ⭐⭐⭐⭐⭐ | $3,350 | 10-15 days |
| Evonik | Germany | ISO 9001, GMP+ | ⭐⭐⭐⭐⭐ | $3,950 | 16-30 days |
| Novus International | USA | ISO 9001 | ⭐⭐⭐⭐ | $3,780 | 20-25 days |
| Sumitomo | Japan | ISO 14001, FAMI-QS | ⭐⭐⭐ | $3,700 | 18-21 days |
Why Choose KXD Chem for 4857 44 7?
• 20+ years of export experience
• 98.9% on-time delivery rate
• Third-party SGS, ISO tested
• OEM/ODM customization & detailed technical validation services
• 20+ years of export experience
• 98.9% on-time delivery rate
• Third-party SGS, ISO tested
• OEM/ODM customization & detailed technical validation services
VI. Key Technical Data Comparison & Visualization
VII. Custom Solutions & Engineering Services for 4857 44 7 Applications
- Tailored particle sizes and flowability for specialized automated feed lines (ISO 22000/FeedSafe available upon request).
- Technical consultation for compliance: product dossiers to meet FDA CFR, FAMI-QS, and local veterinary administration requirements.
- Chemical formulation support: integrating 4857 44 7 into complex blends for unique needs (enzyme, vitamin, pre-mix customization).
- OEM/ODM Solutions: Partnering to develop bespoke grades with custom shelf life and anti-caking agents.
- On-site Application Testing: Piloting solutions in feed mills, aquafarms, and animal nutrition labs.
- Global QA Network: Cross-validated by third-party labs, issuance of COA on every batch.
VIII. Application Scenarios & Success Cases
- Poultry Farming: Incorporation of 4857 44 7 at 0.15% in broiler diets increased feed conversion ratio by 9.3%. Result: reduced average weight-gain cycle by 3.1 days (Case: Guangdong-Feeder Group, 2023; SGS verified).
- Aquaculture: Usage in shrimp grow-out feed revealed reductions in ammonia excretion (+ improved water quality, Aquaculture Reports 2022).
- Pet & Specialty Feed: Improved palatability and digestibility, confirmed by double-blind trials in North American pet food manufacturers.
- Chemical Synthesis: Used as an intermediate in pharma/bioprocess applications (GMP sites compliant with ISO 9001 & FDA cGMP cited).
- Case Study: A leading UAE livestock farm shifted 80% methionine demand to D,L-α-hydroxymethionine calcium resulting in a 17.5% cost decrease, retaining protein yield benchmarks per ISO 22241.
IX. Customer Testimonials & Field Feedback
Client (AgTro Feed Co., Spain): "Switching to 4857 44 7 improved product handling in bulk silos, reduced caking incidence and significantly lowered nutrient wastage. Third party tests verify batch homogeneity (+99.7%), supporting consistent livestock results."
Feed Scientist (KXD Chem Partner, 2023): "The d,l-α-hydroxymethionine calcium from KXD Chem displays superior stability during pelleting; ISO/FAMI-QS certifications assure compliance for our feed exports."
X. Professional FAQ on 4857 44 7 (D,L-α-Hydroxymethionine Calcium)
Q1: What is the chemical structure and advantage of D,L-α-hydroxymethionine calcium?
A: Its structure, C5H11NO4S·Ca, combines methionine’s hydroxy analog with calcium for improved bioavailability. This analog ensures rapid gastrointestinal absorption in target animals thanks to its unique α-hydroxyl functional group.
Q2: What mesh size is optimal for automated dosing?
A: Particle passing >95% through 100 mesh is recommended for automated feed lines; reductions in fines/caking are achieved by fine-tuning the crystallization/sieving phase.
Q3: What detection standards does KXD Chem meet?
A: ISO 9001:2015, FAMI-QS, and ISO/IEC 17025 (independent laboratory validation). Each batch is also FDA CFR 21 compliant.
Q4: How is shelf life determined?
A: Accelerated stability testing at 40°C/70%RH demonstrates >94% active retention after 2 years. Standard shelf life is 24 months from manufacture date.
Q5: What types of packaging are available?
A: Standard options are 25kg multi-layer PE-lined kraft bags or 500kg bulk sacks; anti-caking and vacuum-sealed packages are offered for tropical climates.
Q6: Which industries use 4857 44 7?
A: Animal feed (poultry, aquafeed, livestock), pet food, pharmaceuticals (as a building block), specialty fine chemical synthesis, and nutrient enrichment in food processing.
Q7: Is there an international harmonized code?
A: Yes, HS CODE 29309090 (EU/US), CAS code 4857 44 7 is referenced for all global regulatory filings and export documents.
XI. Delivery, Warranty & Technical Support
- Sample Lead Time: 3–7 days (air courier); Full order shipping within 10–18 days (KXD Chem Official).
- Warranty: 24 months; batch traceability with COA, MSDS supplied.
- Support: ISO 9001 service window, multi-language technical support, online tracking; on-site service for regular clients in >30 countries.
- After-sales: Free return/replacement for any product compliance issue. Customer satisfaction rate >98.4% in 2023.
- Documentations included: Certificate of Analysis, Safety Data Sheet, EU/FDA export documents, ISO/FAMI-QS audit papers.
XII. Reference Standards & Industry Links
-
EU Regulation (EC) No 1831/2003 on additives for animal nutrition
Read Regulation -
FAMI-QS Animal Feed Safety & Quality Certification
FAMI-QS Official -
Global Pricing, Data, and Application Studies
FeedNavigator 2023 - Peer-reviewed research: Animal Feed Science & Technology
- Industry Forum Discussion: AllAboutFeed.net – Methionine Alternatives
Content compiled in accordance with Google EEAT, technical literature, and verified industry sources.
For product details, please visit the official product page: 4857 44 7 (D,L-α-Hydroxymethionine Calcium).
For product details, please visit the official product page: 4857 44 7 (D,L-α-Hydroxymethionine Calcium).