SIDE BY SIDE
Comparing Sevoflurane Options: Specifications, Materials and Supplier Documentation
Procurement teams evaluating Sevoflurane as an inhaled anesthetic API face a common challenge: multiple supplier listings for the same molecule differ in the standards cited, physical-chemical parameters, application notes, and regulatory review documentation. The High Purity Sevoflurane API (Manufacturers/Suppliers listing) and the High Purity Sevoflurane API (China Suppliers and Factory for General Anesthesia listing) cover five criteria: chemical identity and physical parameters, compliance standards, application scope, material compatibility claims, and supply-chain and quality documentation.
High Purity Sevoflurane API Manufacturers China Suppliers Factory (Listing A) — kxdchem.com product page; CAS 28523-86-6; C₄H₃F₇O; supplied by Shijiazhuang Kunxiangda Technology Co., Ltd.
High Purity Sevoflurane API China Suppliers and Factory for General Anesthesia (Listing B) — kxdchem.com product page; CAS 28523-86-6; C₄H₃F₇O; supplied by Shijiazhuang Kunxiangda Technology Co., Ltd.
Introduction
Sevoflurane (1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy) propane; CAS 28523-86-6; molecular formula C₄H₃F₇O; molecular weight 200.055 g/mol) is a halogenated ether used globally as an inhaled anesthetic for the induction and maintenance of general anesthesia in both adult and pediatric patients. Shijiazhuang Kunxiangda Technology Co., Ltd. lists Sevoflurane across multiple product pages, two of which — the High Purity Sevoflurane API Manufacturers China Suppliers Factory listing and the High Purity Sevoflurane API China Suppliers and Factory for General Anesthesia listing — provide sufficiently detailed and independently documented information for a structured side-by-side comparison.
This comparison is bounded to procurement-relevant documentation criteria: what each listing discloses about the substance's identity, the regulatory standards it references, its stated application scope, its material compatibility notes, and the supply-chain and quality assurance details it offers. Neither listing's claims have been independently verified; this article presents them in parallel so buyers can assess documentation completeness before proceeding with due diligence.
Subjects Under Comparison
| Listing A | Listing B | |
|---|---|---|
| Product Name (as listed) | High Purity Sevoflurane API Manufacturers China Suppliers Factory | High Purity Sevoflurane API China Suppliers and Factory for General Anesthesia |
| Source | kxdchem.com product page | kxdchem.com product page |
| CAS Number | 28523-86-6 | 28523-86-6 |
Both listings are supplied by Shijiazhuang Kunxiangda Technology Co., Ltd.
Criterion 1: Chemical Identity and Physical-Chemical Parameters
Both listings document the same core identity and share an identical set of physical-chemical values, as shown below.
| Parameter | Listing A | Listing B |
|---|---|---|
| Chemical Formula | C₄H₃F₇O | C₄H₃F₇O |
| Molecular Weight | 200.055 g/mol | 200.055 g/mol |
| CAS Number | 28523-86-6 | 28523-86-6 |
| Density | 1.505 g/cm³ | 1.505 g/cm³ |
| Boiling Point | 58 °C | 58 °C |
| Refractive Index | 1.266 | 1.266 |
| Steam Pressure | 311 mmHg at 25 °C | 311 mmHg at 25 °C |
| Appearance | Colorless oily liquid | Colorless oily liquid |
| Stability | Stable under normal light | Stable under normal room lighting conditions |
Notable difference: Listing B additionally states that Sevoflurane is "miscible with ethanol, ether, chloroform, and benzene" in its solubility entry, whereas Listing A's published parameters note only that the substance is insoluble in water, without enumerating organic co-solvents. Listing A's description confirms the same miscibility information in its narrative text, but Listing B surfaces it directly in the formal parameters table.
Chemical name: Listing B explicitly lists the IUPAC-style chemical name (1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy) propane) as a dedicated parameters row; Listing A does not include this field in its parameters table.
Criterion 2: Compliance Standards and Regulatory References
Both listings reference overlapping pharmacopoeial and manufacturing standards, with minor differences in how those references are presented.
| Standard / Reference | Listing A | Listing B |
|---|---|---|
| USP (United States Pharmacopeia) | Stated | Stated |
| EP (European Pharmacopeia) | Stated | Stated |
| CP (Chinese Pharmacopeia) | Stated in published excerpt | |
| GMP compliance | Referenced | Referenced |
| IEC 601-2-13 (non-flammable/non-explosive) | Referenced in key advantages | Referenced in safety compliance section |
| API and FDF | Both mentioned | API mentioned; FDF not explicitly enumerated in this listing's excerpt |
Observation: Listing B's published excerpt explicitly mentions CP (Chinese Pharmacopeia) alongside USP and EP. Listing A's published excerpt references USP and EP but does not include CP in the excerpted text for this page. Buyers requiring CP documentation should confirm directly with the supplier which listing's documentation package covers that standard.
Criterion 3: Application Scope
Both listings describe Sevoflurane as suitable for the induction and maintenance of general anesthesia in adult and pediatric patients across inpatient and outpatient surgical settings.
| Application Detail | Listing A | Listing B |
|---|---|---|
| General anesthesia (induction & maintenance) | Yes | Yes |
| Adult patients | Yes | Yes |
| Pediatric patients | Yes | Yes |
| Inpatient settings | Yes | Yes |
| Outpatient settings | Yes | Yes |
| Obstetric anesthesia (with noted precautions) | Not mentioned in this listing | Not mentioned in this listing |
| Delivery via calibrated vaporizer | Specified | Specified |
Note: The general catalog product entry (ref-1) contains detailed obstetric anesthesia application notes, including timing, concentration, and procedural precautions relating to maternal and infant safety. Neither dedicated supplier listing (Listing A or Listing B) reproduces this specific clinical guidance in the excerpted text; buyers with obstetric-use requirements should request the full product documentation accordingly.
Criterion 4: Material Compatibility
Both listings document that Sevoflurane is non-corrosive to a range of surgical-grade metals and equipment materials.
| Material | Listing A | Listing B |
|---|---|---|
| Stainless steel | Non-corrosive | Non-corrosive |
| Aluminum | Non-corrosive | Non-corrosive |
| Brass | Non-corrosive | Non-corrosive |
| Nickel-plated brass / nickel-plated components | Non-corrosive | Non-corrosive |
| Chrome-plated brass | Non-corrosive (stated in ref-1 catalog) | Not enumerated in this listing |
| Copper beryllium | Non-corrosive (stated in ref-1 catalog) | Not enumerated in this listing |
| Additives / chemical stabilizers | None (pure composition stated) | None (pure formulation stated) |
Observation: The detailed enumeration of chrome-plated brass and copper beryllium compatibility appears in the general catalog material (ref-1) rather than in either dedicated listing. Both Listing A and Listing B confirm compatibility with stainless steel, aluminum, brass, and nickel-plated components. Equipment procurement teams requiring compatibility with chrome-plated or copper beryllium components should verify against the full technical data sheet.
Criterion 5: Supply-Chain and Quality Assurance Documentation
| Documentation / Service Element | Listing A | Listing B |
|---|---|---|
| API quality control described | Yes — "Strict adherence to pharmaceutical standards for API to ensure maximum efficacy" | Yes — "Rigorous testing of physical and chemical properties before clinical distribution" |
| Synthesis / purity process described | "Advanced chemical synthesis pipelines ensuring product free of stabilizers or corrosive impurities" | "Direct access to high-purity pharmaceutical intermediates ensuring batch-to-batch consistency" |
| Regulatory compliance documentation | "Full documentation and certification aligning with international chemical and medical regulatory frameworks" | "Rigorous testing of physical and chemical properties" (quality assurance framing) |
| Stability monitoring | "Rigorous testing under varying light and temperature conditions" | "Stable storage under normal room lighting conditions for prolonged shelf-life" |
| Logistics / transport | "Secure packaging and specialized transport for volatile pharmaceutical intermediates" | "Optimized logistics for volatile pharmaceutical chemicals and hazardous material transport" |
| Technical support | "Expert guidance on vaporization calibration and dosage administration" | Not enumerated in this listing's documentation section |
| Precision vaporization compatibility | Referenced in key advantages | Explicitly listed as a dedicated management platform point |
| Safety compliance section | Referenced under key advantages (IEC 601-2-13) | Separately enumerated as a management platform line item |
Observation: Listing A explicitly includes a "Technical Support" point describing vaporization calibration guidance, which does not appear as a separate enumerated item in Listing B's documentation section. Listing B, by contrast, lists "Precision Vaporization" compatibility as its own management platform line, emphasizing calibrated-device delivery. Both address logistics for hazardous/volatile pharmaceutical chemicals, though the phrasing differs slightly. Neither listing specifies minimum order quantities, lead times, or pricing in the approved excerpts.
Summary Comparison Table
| Criterion | Listing A | Listing B |
|---|---|---|
| Physical-chemical parameters | Full table (water solubility only) | Full table + organic miscibility row + chemical name row |
| Pharmacopoeial standards | USP, EP, GMP, IEC 601-2-13 | CP, USP, EP, GMP, IEC 601-2-13 |
| Application scope | Adults, pediatrics, in/outpatient | Adults, pediatrics, in/outpatient |
| Material compatibility | Steel, aluminum, brass, nickel-plated | Steel, aluminum, brass, nickel-plated |
| Technical support documentation | Explicit vaporization guidance noted | Precision vaporization listed as platform item |
| Logistics documentation | Secure packaging + specialized transport | Optimized logistics for hazardous chemicals |
Buyer Considerations
For procurement teams comparing these two Sevoflurane listings from Shijiazhuang Kunxiangda Technology Co., Ltd., the differences are primarily in the level of detail and the specific fields each listing surfaces:
- Regulatory documentation completeness: Buyers requiring CP documentation alongside USP/EP coverage should note that CP is explicitly cited in the Listing B excerpt. Confirmation of which documentation package is available for each listing remains the buyer's due diligence step.
- Parameters detail: Listing B includes the IUPAC chemical name and organic solvent miscibility directly in its parameters table, which may be relevant for formulation and compatibility review.
- Technical support framing: Listing A references vaporization calibration and dosage guidance explicitly, which may be relevant for buyers integrating Sevoflurane into clinical delivery systems for the first time.
- Operating conditions: Both listings confirm use only with specialized, calibrated vaporizers and by personnel trained in general anesthesia. Neither listing provides specific dosing protocols; buyers should consult full clinical documentation and applicable pharmacopoeial monographs.
For product inquiries, contact Shijiazhuang Kunxiangda Technology Co., Ltd. directly through the relevant product pages.
THE COMPANY
Shijiazhuang Kunxiangda Technology Co., Ltd.
Shijiazhuang Kunxiangda Technology Co., Ltd. was established at 2011. we are a professional manufacture for pharmaceutical intermediates and trading company for dye intermediates, and other chemical raw materials. Our factory is located in economic and Technological Development Zone of Shijiazhuang city, Hebei province. Total areas are about 50 acres, and there are more than 300 employees, including 9 technical staffs.…
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