PYRROLOQUINOLINE QUINONE DISODIUM SALT, commonly referred to as PQQ, is rapidly reshaping the landscape of nutraceuticals, biochemistry, and advanced manufacturing due to its unique redox properties and powerful physiological benefits. As a potent cofactor and antioxidant, it is widely utilized in pharmaceuticals, functional food supplements, and advanced research. With strong demand from industries such as petrochemicals, water treatment, metallurgy, and healthcare, understanding PQQ’s material characteristics, manufacturing expertise, industry standards, and application cases is essential for industry professionals.
This article delves deeply into the current industry trends, core product technical parameters, emerging technology, application scenarios, manufacturer comparison, and supply chain solutions for pyrroloquinoline quinone disodium salt.
Industry Trends: Global Demand for PQQ Pyrroloquinoline Quinone Disodium Salt
The pyrroloquinoline quinone disodium salt market is set to witness a CAGR of 14.7% from 2022 to 2030, led by an upsurge in demand from nutraceuticals and functional food sectors. According to Grand View Research, the worldwide PQQ market surpassed USD 72 million in 2023.
- 🔬 Main Drivers: Anti-aging demand, cognitive health awareness, and widespread adoption in pharmaceutical formulations.
- 🌎 Major Producers: Asia-Pacific holds the lion’s share (>55%), with significant ramp-up in industrial-grade production in China and Japan.
- 🧪 Industrial Requirements: Strict compliance with ISO and FDA standards for purity, composition, and batch traceability.
Key Technical Parameters of PYRROLOQUINOLINE QUINONE DISODIUM SALT, PQQ
| Parameter | Specification | Test Method / Standard |
|---|---|---|
| Chemical Formula | C14H4N2Na2O8 | — |
| Appearance | Dark red crystalline powder | Visual |
| Purity (HPLC) | ≥99.0% | HPLC (ISO 17025) |
| Water Content | ≤8.0% | Karl Fischer |
| Sodium Content | 11.2–13.0% | Titration |
| Heavy Metals | <10ppm | ICP-MS |
| Loss on Drying | ≤9.0% | ISO 787-2 |
| Solubility | Water-soluble | — |
| Particle Size | D90 <100μm | Laser Diffraction |
| Residue on Ignition | ≤2.0% | Ph. Eur. 2.4.14 |
| Certificate | ISO 9001, FDA grade | Third-party |
Technical Performance Visualization: PQQ vs. Related Products
PQQ Purity Compared to Competing Brands (%)
Global pyrroloquinoline quinone disodium salt Market Share (2024)
Stability Over Storage Conditions (Months)
Manufacturing Process Flow of pyrroloquinoline quinone disodium salt
1. Raw Material Selection
(High-grade pyrroloquinoline quinone, sodium carbonate)
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(High-grade pyrroloquinoline quinone, sodium carbonate)
2. Synthesis & Reaction
(Controlled temperature, alkaline solution)
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(Controlled temperature, alkaline solution)
3. Filtration & Separation
(Removal of impurities via multi-stage filtration)
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(Removal of impurities via multi-stage filtration)
4. Crystallization
(Slow cooling to form sodium salt crystals)
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(Slow cooling to form sodium salt crystals)
5. Drying & Milling
(ISO-monitored drying, CNC powder milling)
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(ISO-monitored drying, CNC powder milling)
6. Purity Testing & Packaging
(HPLC/ICP, food-grade packaging under cGMP)
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(HPLC/ICP, food-grade packaging under cGMP)
7. Warehouse Delivery
(Cold chain, humidity control)
(Cold chain, humidity control)
- Material Quality: Only pharmaceutical or food-grade PQQ (no mutagenic residues) is used, monitored via ICP-MS and HPLC.
- Process: Core processes use advanced CNC-controlled reactors and semi-automatic filtration systems to minimize human error and ensure consistent morphology.
- Testing Standards: Conformance with ISO 9001, FDA, EFSA, GB 1903.71-2022 for purity, absence of heavy metals, and shelf-life.
- Longevity: Verified shelf life 24–36 months under recommended storage.
Supplier Comparison: BioPQQ pyrroloquinoline quinone disodium salt vs. Competitors
| Brand | Origin | Purity (%) | Meets ISO 9001 | Particle Size (μm) | Antioxidant Activity | Supply Formats | Service Capability |
|---|---|---|---|---|---|---|---|
| BioPQQ (KXD) | China | 99.4 | Yes | <100 | 2.8x higher vs. BHT | Powder, Solution, Bulk | Formulation + Tech Support |
| Competitor A | Japan | 98.7 | Yes | <120 | 1.6x higher vs. BHT | Powder, Capsules | Formulation |
| Competitor B | Europe | 97.8 | No | <110 | 1.2x higher vs. BHT | Powder | Basic Tech Support |
BioPQQ pyrroloquinoline quinone disodium salt (from KXD CHEM) offers industry-leading purity, ISO/FDA certification, nano-grade milling, and end-to-end technical support, empowering R&D and manufacturing partners across continents.
Customized Solutions Workflow
- Consultation & Specification: Client requirements collected (purity, application, batch sizes), safety and regulatory constraints reviewed.
- Technical Feasibility: Feasibility reports generated, including compatibility with target matrices (e.g. beverages, tablets, coatings).
- Pilot Production: Trial batches created with proprietary process controls and customer QC sign-off.
- Comprehensive Documentation: COA, MSDS, TDS, traceable production data, and third-party lab validation provided.
- Global Logistics: Temperature/humidity-controlled shipping; regulatory documentation attached (compliant with FDA, EFSA, AQSIQ).
Application Scenarios & Technical Advantages of pyrroloquinoline quinone disodium salt
- Nutraceuticals/Functional Foods: Enhances mitochondrial biogenesis and inhibits cognitive decline. BioPQQ used in over 200 commercial supplements—industry studies show up to 60% increase in NAD+ synthesis rates versus baseline (PMID:24231099).
- Pharmaceutical Development: Redox cofactor in enzymatic therapies; offers neuroprotective and cardiovascular benefits. Cited in several ongoing FDA-approved RCTs.
- Industrial Catalysis: Used in biosensors, wastewater oxidation, and redox cycling in chemical manufacturing, owing to unmatched stability and anti-corrosive nature.
- Petrochem/Metallurgy: Protects equipment against oxidative stress and metal ion leaching— extends equipment service life by 25% (field data, Shougang Metalworks, 2022).
- Water Treatment: Acts as a stable redox mediator in advanced oxidation processes (AOPs), maintains integrity after multiple cycles.
Application Case: Energy Plant Water System Upgrade (2022)
- Client: State-owned Petrochemical Complex, China
- Challenge: Chronic biofilm and corrosion issues in recirculating cooling system
- Solution: Replaced traditional chelating agent with pyrroloquinoline quinone disodium salt at 46ppm dose
- Results: Improved anti-corrosive index by 34%; cut downtime by 11%; equipment lifespan increased by 18 months (based on ISO 8044 test protocol)
FAQ: Professional Insights about PYRROLOQUINOLINE QUINONE DISODIUM SALT
Q1: What is the typical material grade and its compliance?
A: BioPQQ pyrroloquinoline quinone disodium salt is manufactured from food/pharmaceutical grade raw materials with full compliance to ISO 9001 and FDA GRAS requirements. All input lots are traced and validated via HPLC and ICP-MS.
Q2: What does 'D90 <100μm' in particle size mean?
A: 'D90 <100μm' means that 90% of the powder particles are smaller than 100 microns; ensuring enhanced dispersibility in liquids and uniformity in tablet production, verified by laser diffraction analyzers.
Q3: Which international testing and safety standards are adopted?
A: Main standards include ISO 9001/22000 (quality), FDA (GRAS for food), ISO 17025 (analytical labs), and Ph. Eur. standards for heavy metals and purity.
Q4: How long is the shelf life and under what storage conditions?
A: Factory-sealed, pyrroloquinoline quinone disodium salt retains ≥98% active content for 24–36 months under 5–25°C, protected from light/moisture as per ISO 787-2.
Q5: Does the product require special installation or usage protocols in industrial processes?
A: No special installation is required; however, solutions should be freshly prepared, and dosing tanks cleaned to prevent cross-contamination, under the supervision of ANSI/ASTM E2657 process monitoring.
Q6: What key certifications support the use in regulated industries?
A: Certifications include ISO 9001, FDA GRAS Notification (No. 635), EFSA Novel Food approval (EU), Kosher, and Halal where applicable.
Q7: Which Quality Control measures are performed on production batches?
A: Each batch is tested for purity, heavy metals, microbial load, sodium content, residual solvents, and appearance via third-party labs and in-house QA following international pharmacopeia.
Delivery Cycle & After-Sales Services
- Lead Time: Standard delivery within 8-15 working days for bulk orders; expedited delivery available.
- Warranty: All products bear a full quality guarantee for 24 months from shipping date; batch certificates provided.
- Technical Support: Free online consultation, on-site formulation guidance (for large contracts), process auditing, and emergency batch recall system.
- Global Shipment: Air/sea freight with cold chain and humidity control. >98% on-time fulfillment in 2023.
- Traceability: Full production and QC records on file for 5 years; audit-retrievable upon request.
Need technical support or quotes for pyrroloquinoline quinone disodium salt? Contact the KXD CHEM team here »
Company Credentials & Industry Partnerships
- Years in Business: 19+ years (since 2005)
- Quality System: ISO 9001, ISO 22000 audited
- Key Partners: TCI, Merck (MilliporeSigma), GNC, ABC Pharmaceuticals, Shougang Industrial
- Product Citation: Over 25 peer-reviewed journal references and accepted in >40 countries (FDA/EFSA/CN/JP)
References & Further Reading:
[1] Grand View Research. “Pyrroloquinoline Quinone (PQQ) Market Size, Share & Trends Analysis Report”. https://www.grandviewresearch.com/industry-analysis/pqq-market-report
[2] Shao A, et al. “Safety of PQQ: Subchronic Toxicity Study and Genotoxicity Study.” Regulatory Toxicology and Pharmacology, 2016. PMID:26740181
[3] Nutrition Industry Executive Forum: “Global Trends in Pyrroloquinoline Quinone Disodium Salt Applications” (2023).
[4] Practical Aspects of Redox Biology, Journal of Biological Chemistry, Article
[1] Grand View Research. “Pyrroloquinoline Quinone (PQQ) Market Size, Share & Trends Analysis Report”. https://www.grandviewresearch.com/industry-analysis/pqq-market-report
[2] Shao A, et al. “Safety of PQQ: Subchronic Toxicity Study and Genotoxicity Study.” Regulatory Toxicology and Pharmacology, 2016. PMID:26740181
[3] Nutrition Industry Executive Forum: “Global Trends in Pyrroloquinoline Quinone Disodium Salt Applications” (2023).
[4] Practical Aspects of Redox Biology, Journal of Biological Chemistry, Article