In recent years, with the continuous progress of modern medicine and technology, the research and innovation of narcotic drugs have also achieved remarkable results. As a new anesthetic for inhalation, เซโวฟลูเรน has gradually replaced traditional anesthetics, such as halothane and isoflurane, and become a widely used anesthetic worldwide. Since its appearance in the early 1990s, เซโวฟลูเรน has been widely used in general anesthesia, children anesthesia, elderly anesthesia and other fields because of its excellent anesthetic effect, lower side effects and milder metabolic characteristics.
Know Sevoflurane
Before เซโวฟลูเรน appeared, halothane and isoflurane were commonly used as active drugs in inhalation anesthesia. However, halothane and isoflurane are often accompanied by some adverse reactions in clinical use, especially halothane, which may cause toxic reactions to the liver, limiting its long-term use. In addition, although isoflurane has a good anesthetic effect, its side effects on cardiovascular system and relatively slow recovery rate have brought great challenges to clinicians.
เซโวฟลูเรน appeared to solve these problems. The chemical structure of เซโวฟลูเรน is optimized on the basis of traditional anesthetic active drug components, which can provide faster anesthesia induction, lower side effects and faster postoperative recovery time. Its high anesthetic effect and low hepatorenal toxicity make it a new choice for clinical anesthesia.
Deficiency and Potential Risk of Sevoflurane
Cost problem
The cost of เซโวฟลูเรน is relatively high, which may limit its use in some areas with less favorable economic conditions. Although its superior anesthetic effect and low side effects make เซโวฟลูเรน perform well in many high-risk operations, its cost is still a factor that many medical institutions must consider.
Potential metabolic toxicity
Some toxic substances such as fluoride may be produced during the metabolism of เซโวฟลูเรน. Although these metabolites have little effect on the liver, they may still cause certain liver damage in some patients. Therefore, for patients with basic liver diseases, เซโวฟลูเรน should be used with special caution.
Respiratory reaction
Although เซโวฟลูเรน is less irritating to respiratory tract, in some cases, it may still cause respiratory spasm, cough and other reactions, especially in children and patients with sensitive airway. Anesthesiologists need to closely monitor the patient's breathing during anesthesia in order to adjust the anesthesia plan in time.
Future Development of Sevoflurane
With the continuous development of anesthesiology, the clinical application of เซโวฟลูเรน will be more extensive. In the future, เซโวฟลูเรน may play a greater role in the combined use of new anesthetic techniques and new anesthetic drugs. For example, เซโวฟลูเรน and neuromodulation technology.The combination of the two methods may make the anesthetic effect more accurate and the postoperative recovery more rapid.
In addition, with the deepening research on the metabolic process and long-term use safety of เซโวฟลูเรน, the side effects and potential risks of เซโวฟลูเรน may be further effectively controlled, so that it can be used in more patient groups.