High-Purity Methylurea Compounds for Chemical Synthesis

1. Industry Trends and Market Dynamics for Methylurea

The global market for methylurea and its derivatives, including dimethylurea, 1 methylurea, and 1 3 dimethylurea, is experiencing steady growth, propelled by burgeoning demand in agrochemicals, pharmaceuticals, and specialty chemicals. Recent market analyses project a Compound Annual Growth Rate (CAGR) of approximately 5.8% for urea-based compounds from 2023 to 2028, primarily driven by their versatility as building blocks for complex organic synthesis and their increasing adoption as non-toxic alternatives in various formulations. Emerging trends indicate a shift towards higher purity grades and custom syntheses, particularly for sensitive applications such as the production of certain n nitroso n methylurea derivatives used in advanced research and medical applications, requiring stringent quality controls.

Innovations in synthetic pathways are making production more efficient and environmentally friendly. For instance, the demand for precise control over isomer formation in compounds like 3 3 4 dichlorophenyl 1 1 dimethylurea underscores the need for sophisticated manufacturing processes and analytical capabilities. Manufacturers like KXDCHEM are at the forefront, adapting to these trends by investing in R&D to meet the evolving purity and application-specific needs of the market, ensuring a reliable supply of high-grade methylurea.

2. Technical Parameters and Specifications of Methylurea

Methylurea (CAS No. 598-50-5) is a versatile organic compound with a distinct chemical profile that makes it invaluable across multiple sectors. Its molecular structure provides excellent reactivity, making it a crucial intermediate in organic synthesis. Below is a detailed table summarizing key technical parameters of typical high-purity Methylurea as supplied by leading manufacturers, demonstrating the precision and quality standards maintained in its production.

Parameter	Specification (Typical)	Test Method/Standard	Significance
Chemical Formula	CH₃NHCONH₂	IUPAC Nomenclature	Fundamental molecular structure.
Molecular Weight	74.08 g/mol	Calculated	Crucial for stoichiometric calculations in reactions.
Purity	≥ 99.0% (HPLC)	HPLC, GC-MS (ISO 17025 certified lab)	Essential for consistent reaction outcomes and reduced impurities in end products.
Appearance	White Crystalline Powder	Visual Inspection	Indicates proper crystallization and absence of foreign matter.
Melting Point	99-102 °C	DSC (Differential Scanning Calorimetry)	Key physical constant for identification and purity assessment. A narrow range indicates high purity.
Water Content	≤ 0.5%	Karl Fischer Titration (ASTM E1064)	Low moisture content prevents side reactions and ensures stability.
pH (1% soln.)	6.0 - 8.0	pH Meter (25°C)	Indicates neutrality, important for solution stability and compatibility.
Solubility	Soluble in Water, Ethanol; Slightly soluble in Ether	Observation	Determines suitability for various solvent systems in industrial processes.
Ash Content	≤ 0.1%	Gravimetric Analysis (ASTM D482)	Measures inorganic impurities, crucial for applications requiring high purity.
Heavy Metals	≤ 10 ppm	ICP-MS (Inductively Coupled Plasma - Mass Spectrometry)	Critical for pharmaceutical and agricultural applications to ensure safety and compliance with regulatory limits (e.g., FDA guidelines).

These specifications are rigorously tested and maintained to ensure that KXDCHEM's Methylurea consistently meets the highest industry benchmarks, providing reliability and performance for our clients.

3. Applications of Methylurea Across Industries

The versatility of Methylurea makes it an indispensable compound across a wide array of industrial applications. Its unique chemical properties allow it to serve as a key intermediate or a direct component in various formulations.

Agrochemicals: Methylurea is a crucial building block in the synthesis of several herbicides, fungicides, and plant growth regulators. For instance, it is a precursor for certain urea-based herbicides, contributing to enhanced crop protection and yield. Its controlled release properties can also be leveraged in advanced fertilizer formulations, ensuring more efficient nutrient delivery and reduced environmental impact.
Pharmaceuticals: In the pharmaceutical industry, high-purity Methylurea serves as a vital intermediate for synthesizing active pharmaceutical ingredients (APIs). It plays a role in the production of drugs targeting various ailments, often as a source of nitrogen for heterocyclic compounds. Examples include its use in creating specific heterocyclic amines and amides found in modern therapeutics.
Specialty Chemicals: Beyond traditional uses, Methylurea finds application in the synthesis of specialty chemicals. This includes the production of dyes, pigments, and certain types of resins. Its reactivity facilitates the formation of complex structures, imparting desirable properties like color stability or improved material strength.
Research & Development: Given its well-defined chemical structure and reactivity, Methylurea is widely utilized in academic and industrial research labs as a reagent for developing new synthetic pathways and novel compounds. It is frequently employed in studies involving organic synthesis and medicinal chemistry.
Polymers and Resins: In some instances, Methylurea or its derivatives like dimethylurea can be incorporated into polymer formulations or resin systems to modify properties such as flame retardancy or adhesive characteristics.

The expanding scope of applications for Methylurea underscores its significance as a foundational chemical. KXDCHEM provides grades suitable for these diverse applications, ensuring consistent quality that meets industry-specific requirements.

4. Technical Advantages of KXDCHEM's Methylurea

At KXDCHEM, our commitment to excellence is reflected in the superior technical advantages of our Methylurea. We integrate advanced manufacturing techniques and rigorous quality control to deliver a product that stands out in the market.

Purity and Consistency: Our Methylurea boasts a minimum purity of 99.0% as verified by High-Performance Liquid Chromatography (HPLC) and Gas Chromatography-Mass Spectrometry (GC-MS). This high purity ensures minimal impurities, which is critical for sensitive applications in pharmaceuticals and fine chemicals, preventing undesirable side reactions and ensuring consistent yield and quality of end products. Our batch-to-batch consistency is a hallmark of our production, ensuring seamless integration into your processes.

Optimized Reactivity: The precise synthesis process we employ yields Methylurea with optimal crystal structure and low moisture content (≤ 0.5%), contributing to enhanced reactivity and stability. This means faster reaction times and higher conversion rates for our clients, translating into improved process efficiency and cost savings.

Exceptional Thermal Stability: Our product exhibits excellent thermal stability, with a well-defined melting point range of 99-102 °C. This characteristic is crucial for processes involving elevated temperatures, ensuring the integrity of the compound and preventing degradation during storage, transport, and reaction. This reliability prevents unexpected process interruptions and maintains product quality.

Environmental Responsibility: KXDCHEM is committed to sustainable manufacturing. Our production processes are designed to minimize waste and reduce energy consumption, aligning with international environmental standards. We ensure that our Methylurea is produced with minimal environmental footprint without compromising on quality or performance. This commitment extends to careful handling and packaging to prevent any adverse impacts.

High-Purity Methylurea Compounds for Chemical Synthesis

Figure 1: Microscopic view of high-purity Methylurea crystals, illustrating its consistent morphology.

4.1. Detailed Manufacturing Process of Methylurea at KXDCHEM

The manufacturing of Methylurea at KXDCHEM involves a meticulously controlled multi-stage process, ensuring the highest standards of purity, consistency, and yield. Our process adheres strictly to ISO 9001:2015 quality management systems, incorporating robust in-process and final product quality checks.

Step 1: Raw Material Sourcing & Preparation

We begin with high-quality raw materials, typically Methylamine and Urea, sourced from audited, reputable suppliers. These raw materials undergo stringent incoming quality control (IQC) checks, including purity analysis (e.g., GC for Methylamine, titration for Urea), moisture content, and heavy metal screening, to ensure they meet our internal specifications. Impurities at this stage are a major cause of downstream contamination.

Step 2: Reaction & Synthesis

The synthesis of Methylurea involves a controlled reaction between Methylamine and Urea under specific temperature and pressure conditions within precisely engineered stainless steel reactors. This amidation reaction is carefully monitored to optimize conversion rates and minimize side-product formation. We employ advanced control systems (DCS/PLC) to maintain optimal parameters, such as pH, temperature, and reaction time, which are critical for selective product formation and avoiding the creation of unwanted by-products like dimethylurea or 1 3 dimethylurea.

Step 3: Purification & Crystallization

Following the primary reaction, the crude Methylurea solution undergoes a series of purification steps. This typically includes filtration to remove insoluble impurities, followed by precise crystallization. The crystallization process is finely tuned to control crystal size and morphology, ensuring easy handling and high purity. This often involves controlled cooling and solvent selection, followed by solid-liquid separation via centrifugation.

Step 4: Washing & Drying

The crystallized Methylurea is then thoroughly washed with deionized water or an appropriate solvent to remove residual mother liquor and soluble impurities. This washing step is critical for achieving the high purity levels required by our clients. Subsequently, the wet cake is transferred to a vacuum dryer or fluidized bed dryer where moisture content is reduced to less than 0.5%, preventing degradation and ensuring long-term stability.

Step 5: Quality Control & Packaging

The final dried Methylurea undergoes comprehensive final quality control (FQC) testing. This includes purity analysis via HPLC, melting point determination, water content (Karl Fischer), heavy metal analysis (ICP-MS), and particle size distribution. Only batches meeting all stringent specifications are released. The product is then carefully packaged in multi-layer bags or drums under inert atmosphere to prevent contamination and moisture absorption, ensuring safe transport and extended shelf life. All packaging adheres to UN packaging standards for chemical goods, guaranteeing safety during logistics.

This stringent process, coupled with continuous process improvement initiatives, enables KXDCHEM to produce Methylurea of exceptional quality, ensuring reliability and performance for industries such as petrochemicals (as an intermediate), metallurgy (for specific surface treatments), and fine chemical synthesis where purity is paramount.

5. Manufacturer Comparison and KXDCHEM's Advantage

In a competitive market for specialty chemicals, choosing the right supplier for Methylurea is paramount. While numerous manufacturers exist globally, KXDCHEM distinguishes itself through a unique blend of experience, technical prowess, and unwavering commitment to quality. Here's how we compare:

Feature/Aspect	Typical Competitor	KXDCHEM's Advantage
Product Purity	Often 98-99% with varying impurity profiles.	Consistently ≥ 99.0% (HPLC), with ultra-low heavy metal and ash content. Our methylurea purity is independently verified.
Quality Control	Standard in-house checks; sometimes outsource.	Integrated, multi-stage QC (IQC, IPC, FQC) utilizing advanced analytical instruments (HPLC, GC-MS, ICP-MS, DSC). Adherence to ISO 9001:2015 for our methylurea production.
Manufacturing Process	Batch processing with less automation.	Optimized, semi-automated process with precise parameter control, leading to superior batch consistency and higher yield. Our methylurea process reduces environmental impact.
Technical Support & R&D	Limited post-sale support; basic R&D.	Dedicated technical support team, offering application guidance and troubleshooting. Robust R&D for custom syntheses and new product development like specialized dimethylurea derivatives.
Certifications & Compliance	Basic regional certifications.	International certifications (ISO 9001, REACH compliance), ensuring global market access and adherence to stringent environmental and safety standards. This covers all our methylurea products.
Supply Chain Reliability	Potential for disruptions, inconsistent lead times.	Strong global logistics network, secure warehousing, and contingency planning ensure consistent supply and on-time delivery. Over 20 years of experience in chemical distribution for methylurea.
Customization Capabilities	Limited or no customization options.	Extensive capability for custom synthesis of various methylurea grades and related compounds, tailored to specific client requirements (e.g., particle size, specific impurity profiles for 1 3 dimethylurea).

Our commitment to continuous improvement and customer satisfaction sets us apart. KXDCHEM isn't just a supplier; we are a strategic partner invested in your success, offering a reliable, high-quality source of Methylurea and comprehensive support.

6. Custom Solutions and Tailored Methylurea Grades

Recognizing that industrial applications often demand more than off-the-shelf products, KXDCHEM excels in providing custom solutions for Methylurea and its derivatives. Our R&D team works closely with clients to understand their unique process requirements, performance specifications, and regulatory challenges. This collaborative approach allows us to develop and manufacture bespoke grades of Methylurea with specific characteristics.

Our customization capabilities include:

Particle Size Optimization: We can fine-tune the crystallization process to achieve specific particle size distributions, which is critical for applications like precise dosing in pharmaceutical formulations or enhanced solubility in agrochemical sprays.
Impurity Profile Control: For highly sensitive applications, we can implement additional purification steps or select specific raw material batches to minimize trace impurities, even those not typically screened, such as particular isomers or heavy metals below standard detection limits for n nitroso n methylurea precursors.
Moisture Content Adjustment: While our standard product has low moisture, some processes may require even lower levels or specific hydration states. We can adjust drying parameters to meet these precise needs.
Packaging Solutions: From bulk bags to small, inert-atmosphere container111s, we offer flexible packaging options designed to maintain product integrity and safety during transport and storage, minimizing material handling risks and waste.
Derivative Synthesis: Beyond pure Methylurea, we have the expertise to synthesize related compounds like various forms of dimethylurea or 1 methylurea with customized purity and specifications, serving as a single-source solution for complex chemical needs.

Our dedicated project management team ensures transparency and efficiency throughout the custom synthesis process, from initial consultation and feasibility studies to pilot scale-up and full production. This client-centric approach has resulted in numerous successful collaborations, cementing our reputation as a flexible and reliable partner for specialty chemical needs.

7. Application Cases & Client Success Stories

KXDCHEM's high-purity Methylurea has been successfully deployed in a multitude of demanding industrial applications, demonstrating its reliability and superior performance. Here are a few examples showcasing the impact of our product:

Case Study 1: Enhanced Herbicide Efficacy for a Leading Agrochemical Firm

Challenge: A major agrochemical producer sought to improve the active ingredient purity and consistency of their urea-based herbicide formulation, which previously suffered from variable efficacy due to inconsistent raw material quality.

Solution: KXDCHEM provided a custom-grade Methylurea with ultra-high purity (>99.5%) and a controlled particle size. Our technical team worked with their R&D department to optimize the integration of our methylurea into their synthesis process.

Result: The client reported a significant improvement in the final herbicide purity and a 15% increase in efficacy in field trials, attributed directly to the higher quality and consistency of our methylurea. This led to a reduced dosage requirement for their end-users, enhancing cost-effectiveness and environmental benefits.

Case Study 2: Optimized API Synthesis in the Pharmaceutical Industry

Challenge: A pharmaceutical company encountered issues with trace impurities from their existing Methylurea supply, which affected the yield and purity of a critical Active Pharmaceutical Ingredient (API). Specifically, the presence of specific 1 3 dimethylurea isomers was problematic.

Solution: KXDCHEM developed a specialized Methylurea grade with an exceptionally low content of specific organic impurities, including targeted dimethylurea isomers, verified by sensitive GC-MS methods. Our rigorous quality control ensured batch-to-batch consistency.

Result: The client observed a 5% increase in API yield and a significant reduction in purification steps, leading to substantial cost savings and accelerated production cycles. Our methylurea became their preferred choice for this critical synthesis.

Case Study 3: Stable Intermediate for Advanced Polymer Manufacturing

Challenge: A manufacturer of high-performance engineering polymers required a highly stable and reactive intermediate. Previous suppliers' Methylurea exhibited inconsistent thermal stability, leading to variability in polymer properties.

Solution: KXDCHEM supplied Methylurea known for its exceptional thermal stability and consistent reactivity, a direct result of our stringent drying and purification processes. We provided detailed thermal analysis data (TGA/DSC) to assure them of its performance.

Result: The client reported a marked improvement in the consistency of their final polymer's mechanical properties and a reduction in batch rejections by 10%. This enabled them to achieve tighter product specifications and enhance their market competitiveness, solidifying our reputation as a reliable supplier of high-quality methylurea.

These cases exemplify KXDCHEM's commitment to delivering not just a product, but a solution that addresses specific client needs, fostering long-term partnerships built on trust and demonstrated expertise.

8. Frequently Asked Questions (FAQ) about Methylurea

Q1: What is the primary use of Methylurea in the chemical industry?

A1: The primary use of Methylurea is as a key intermediate in the synthesis of a wide range of organic compounds. It is particularly valued in the agrochemical industry for herbicides and fungicides, and in the pharmaceutical sector for various active pharmaceutical ingredients (APIs). It serves as a versatile building block for nitrogen-containing structures.

Q2: How does KXDCHEM ensure the high purity of its Methylurea?

A2: KXDCHEM ensures high purity through a multi-stage process involving rigorous raw material inspection, precise reaction control, advanced purification techniques including controlled crystallization and thorough washing, and a comprehensive final quality control (FQC) analysis. We utilize analytical methods such as HPLC, GC-MS, and ICP-MS and adhere to ISO 9001:2015 standards to guarantee methylurea purity exceeding 99.0%.

Q3: Can KXDCHEM provide custom grades of Methylurea?

A3: Yes, KXDCHEM specializes in providing custom solutions. We can tailor Methylurea grades based on specific requirements such as particle size distribution, very low trace impurity levels (e.g., for specific dimethylurea isomers), controlled moisture content, and specialized packaging, working closely with clients to meet their unique application needs.

Q4: What are the typical packaging options for Methylurea?

A4: Our Methylurea is typically packaged in multi-layer Kraft paper bags with an inner polyethylene liner (25kg net weight) or fiber drums (50kg net weight), designed to protect the product from moisture and contamination. Custom packaging solutions, including bulk bags or smaller container111s, are available upon request.

Q5: What are the typical lead times and delivery processes for Methylurea orders?

A5: Standard lead times for Methylurea orders typically range from 7-14 business days, depending on order size and destination. For custom or large-volume orders, lead times will be confirmed individually. We leverage a robust global logistics network to ensure efficient and reliable delivery, adhering to international shipping regulations and providing full tracking information.

Q6: What quality certifications does KXDCHEM hold for its products, including Methylurea?

A6: KXDCHEM operates under an ISO 9001:2015 certified quality management system, ensuring consistent product quality and customer satisfaction across all our chemical products, including Methylurea. We also ensure our products comply with relevant international regulatory standards like REACH, where applicable, providing a robust framework of trust and reliability.

Q7: What is the recommended storage and handling procedure for Methylurea?

A7: Methylurea should be stored in a cool, dry, well-ventilated area, away from incompatible materials, direct sunlight, and sources of ignition. Keep container111s tightly closed. When handling, use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a dust mask. Refer to the product's Safety Data Sheet (SDS) for detailed safety information and emergency procedures.

9. Trust and Reliability: KXDCHEM's Commitment

KXDCHEM has built a reputation for reliability and trustworthiness over two decades in the specialty chemical industry. Our dedication to quality extends beyond product specifications to every aspect of our operations, ensuring peace of mind for our partners.

9.1. Quality Assurance and Certifications

Our commitment to excellence is underpinned by stringent quality assurance protocols. All production facilities adhere to the ISO 9001:2015 Quality Management System, signifying our dedication to continuous improvement and customer satisfaction. Each batch of Methylurea undergoes comprehensive testing in our state-of-the-art laboratories, equipped with advanced analytical instrumentation to verify purity, composition, and physical properties. This rigorous testing ensures that our products consistently meet or exceed industry standards, providing reliable performance in critical applications.

9.2. Delivery and Supply Chain Excellence

Understanding the critical nature of timely supply in the chemical industry, KXDCHEM has established a robust global logistics network. We manage a secure and efficient supply chain, from raw material sourcing to final product delivery, ensuring that your Methylurea orders arrive on schedule and in pristine condition. Our experienced logistics team navigates international shipping regulations with expertise, providing comprehensive documentation and tracking for every shipment. We pride ourselves on transparent communication regarding delivery schedules and potential contingencies, building strong, dependable partnerships.

9.3. Warranty and Customer Support

KXDCHEM stands behind the quality of its Methylurea with a clear product warranty, guaranteeing that our products meet published specifications. Should any issues arise, our dedicated customer support team and technical experts are readily available to provide assistance, troubleshooting, and in-depth technical guidance. We believe in fostering long-term relationships through proactive support and responsiveness, ensuring that our clients can confidently integrate our methylurea into their processes. Our service doesn't end with delivery; it's a continuous partnership.