Iyini Indlela Yesenzo ye-Sevoflurane?

I-Sevoflurane iyisidakamizwa esisetshenziswa kabanzi sokuhogela esidlala indima ebalulekile kwezokwelapha zesimanje. Isetshenziselwa ukuheha nokugcina i-anesthesia ejwayelekile ngesikhathi sokuhlinzwa. Kodwa ingabe wake wazibuza ukuthi le nhlanganisela ephawulekayo isebenza kanjani umlingo wayo? Kulesi sihloko, sizocubungula indlela eyinkimbinkimbi yokwenza i-sevoflurane futhi sihlole ukuthi iletha kanjani isimo sokubulala izinzwa ezigulini.

Izisekelo ze-Sevoflurane

Ngaphambi kokuthi singene endleleni yokusebenza, kubalulekile ukuqonda ukuthi iyini i-sevoflurane. I-Sevoflurane iyi-anesthetic yokuhogela eguquguqukayo elawulwa ngokuhogela. Ivamise ukulethwa ezigulini ngomshini wokulalisa izinzwa futhi ihogele ngemaski noma ngeshubhu le-endotracheal.

Ukukhomba Uhlelo Lwezinzwa Olumaphakathi

Indawo eyinhloko yesenzo se-sevoflurane yisistimu yezinzwa emaphakathi (CNS). Isebenza ebuchosheni nasemgogodleni ukuze ikhiqize ukulahlekelwa ukwazi okujulile nokuhlehlayo. Lokhu kufezwa ngokushintsha ukudluliswa kwezimpawu zezinzwa ezindaweni ezihlukahlukene ze-CNS.

Ukuguqulwa kwe-Neurotransmitters

I-Sevoflurane ngokuyinhloko yenza imiphumela yayo ngokuguqula ama-neurotransmitters, okuyizithunywa zamakhemikhali ezidlulisa amasignali phakathi kwamaseli ezinzwa. Enye yama-neurotransmitters abalulekile athintwa yi-sevoflurane i-gamma-aminobutyric acid (GABA). I-GABA iyi-neurotransmitter evimbelayo edambisa ukusebenza kwamangqamuzana ezinzwa, okuholela kumphumela wokuzola ebuchosheni.

Ukuthuthukisa Umsebenzi we-GABA

I-Sevoflurane ithuthukisa umsebenzi we-GABA ngokubophezela kumasayithi athile ama-receptor kumaseli ezinzwa. Lapho ama-molecule e-sevoflurane ebophezela kulawa ma-receptors, kwandisa ukusebenza kahle kwe-GABA ekuvimbeleni umsebenzi wamaseli wezinzwa. Lokhu kubangela ukucindezelwa kokudubula kwe-neuronal, okuholela ekugcineni ekulahlekelweni ukwazi okutholwa yisiguli.

Ukuvimbela Izimpawu Ezijabulisayo

Ngaphezu kokuthuthukisa umsebenzi we-GABA, i-sevoflurane futhi ivimbela ukudluliswa kwamasignali ajabulisayo. Amasignali ajabulisayo anesibopho sokuvuselela amaseli ezinzwa nokukhuthaza ukuphaphama. Ngokuphazamisa lezi zibonakaliso, i-sevoflurane iqhubeka ifaka isandla ekufakweni kwe-anesthesia.

Umthelela Kwamanye Ama-Neurotransmitters

Indlela yokusebenza ye-Sevoflurane ayikhawulelwe ku-GABA namasiginali ajabulisayo. Iphinde ithinte nezinye izinhlelo ze-neurotransmitter, kuhlanganise nesistimu ye-glutamate. I-Glutamate iyi-neurotransmitter ejabulisayo, futhi i-sevoflurane inganciphisa ukukhululwa kwayo kanye nemiphumela, ngokuqhubekayo ibe nomthelela ekucindezelekeni okuphelele kwe-CNS okubonwa ngesikhathi sokulala.

Ukugcina i-Anesthesia

Nakuba i-sevoflurane iphumelela ekudambiseni izinzwa, ibaluleke ngokufanayo ekuyigcineni kuyo yonke inqubo yokuhlinzwa. Izazi zokubulala izinzwa zilawula ngokucophelela ukugcwala kwe-sevoflurane egazini lesiguli ukuze kuqinisekiswe isimo esijulile nesizinzile sokubulala izinzwa. Lokhu kulawulwa okunembile kuvumela isiguli ukuthi sihlale singazi inqubo yokuhlinzwa kanye nanoma yikuphi ukungakhululeki okuhlobene.

Ukubuyisela kanye nokuqedwa

Uma inqubo yokuhlinzwa isiqediwe, i-sevoflurane iyekwa, futhi isiguli siqala ukululama. Ukuqedwa kwe-sevoflurane emzimbeni kwenzeka ngokuyinhloko ngokukhipha umoya. Isiguli siyaqhubeka nokuphefumula i-sevoflurane esele kuze kube yilapho ukugxila egazini kufinyelela ezingeni eliphephile lokuvuka. Le nqubo ngokuvamile iholela ekululameni okusheshayo nokushelelayo.

Ukuphepha kanye Nokuqapha

Kukho konke ukuphathwa kwe-sevoflurane, ukuphepha kwesiguli kubaluleke kakhulu. Izazi zokubulala izinzwa kanye namaqembu ezokwelapha ziqapha ngokucophelela izimpawu ezibalulekile, okuhlanganisa ukushaya kwenhliziyo, umfutho wegazi, namazinga komoya-mpilo, ukuze kuqinisekiswe ukuthi isiguli sihlala sizinzile phakathi nenqubo. Lokhu kuqapha ngokucophelela kusiza ukuvimbela izinkinga futhi kuqinisekisa umphumela wokuhlinzwa ophumelelayo.

Isiphetho

Kafushane, indlela yokusebenza ye-sevoflurane ihilela umthelela wayo ohlelweni lwezinzwa olumaphakathi, lapho ithuthukisa khona umsebenzi wama-neurotransmitters angavimbeli njenge-GABA, ivimbe amasignali ajabulisayo, futhi iguqule ezinye izinhlelo ze-neurotransmitter. Lokhu kubangela ukungeniswa nokugcinwa kwe-anesthesia ejwayelekile, okuvumela iziguli ukuthi zenze izinqubo zokuhlinzwa ngokunethezeka nangokuphephile.

Uma unanoma yimiphi imibuzo mayelana ne-sevoflurane noma udinga umhlinzeki othembekile wemishini yezokwelapha nemithi, sicela ungangabazi Xhumana nathi. Silapha ukuze sikunikeze ulwazi nokwesekwa okudingayo ukuze uqinisekise ukuphepha nokuphila kahle kweziguli zakho ngesikhathi sokuphathwa kwezinzwa. Impilo yakho kanye nempilo yeziguli zakho kuyizinto eziza kuqala kithi.