Kodi Njira Yogwirira Ntchito ya Sevoflurane ndi Chiyani?

Sevoflurane ndi mankhwala omwe amagwiritsidwa ntchito kwambiri pokoka mpweya omwe amagwira ntchito yofunika kwambiri pazamankhwala amakono. Amagwiritsidwa ntchito pokopa ndi kusunga anesthesia wamba panthawi ya opaleshoni. Koma kodi munayamba mwadzifunsapo momwe gulu lodabwitsali limagwirira ntchito zamatsenga? M'nkhaniyi, tiwona momwe sevoflurane imagwirira ntchito movutikira ndikuwunika momwe zimabweretsera vuto la opaleshoni mwa odwala.

Zoyambira za Sevoflurane

Tisanalowe munjira yochitira zinthu, ndikofunikira kumvetsetsa kuti sevoflurane ndi chiyani. Sevoflurane ndi mankhwala osokoneza bongo omwe amaperekedwa kudzera mu mpweya. Nthawi zambiri amaperekedwa kwa odwala kudzera mu makina opangira opaleshoni ndipo amakokedwa kudzera mu chigoba kapena endotracheal chubu.

Kulimbana ndi Central Nervous System

Malo oyambirira a sevoflurane ndi dongosolo lapakati la mitsempha (CNS). Zimagwira ntchito muubongo ndi msana kuti zipangitse kutayika kwakukulu komanso kosinthika kwa chidziwitso. Izi zimatheka mwa kusintha kufalitsa kwa zizindikiro za mitsempha m'madera osiyanasiyana a CNS.

Kusintha kwa Neurotransmitters

Sevoflurane makamaka imakhala ndi zotsatira zake posintha ma neurotransmitters, omwe ndi amithenga amankhwala omwe amatumiza mauthenga pakati pa maselo a mitsempha. Chimodzi mwazinthu zazikulu za neurotransmitters zomwe zimakhudzidwa ndi sevoflurane ndi gamma-aminobutyric acid (GABA). GABA ndi inhibitory neurotransmitter yomwe imachepetsa ntchito ya ma cell a mitsempha, zomwe zimapangitsa kuti ubongo ukhale wodekha.

Kupititsa patsogolo ntchito ya GABA

Sevoflurane imathandizira ntchito ya GABA pomanga malo ena olandirira pama cell a mitsempha. Pamene mamolekyu a sevoflurane amamangiriza ku zolandilira izi, zimawonjezera mphamvu ya GABA poletsa ntchito zama cell minyewa. Izi zimabweretsa kuponderezedwa kwa kuwombera kwa neuronal, komwe pamapeto pake kumabweretsa kutayika kwa chidziwitso komwe wodwalayo amakhala.

Kuletsa Zizindikiro Zosangalatsa

Kuphatikiza pa kupititsa patsogolo ntchito za GABA, sevoflurane imalepheretsanso kufalikira kwa ma sign osangalatsa. Zizindikiro zochititsa chidwi ndizolimbikitsa ma cell a mitsempha ndikulimbikitsa kugalamuka. Mwa kusokoneza zizindikirozi, sevoflurane imathandiziranso kulowetsedwa kwa anesthesia.

Zokhudza Ma Neurotransmitters Ena

Kachitidwe ka Sevoflurane sikungokhala ku GABA komanso ma siginecha osangalatsa. Zimakhudzanso machitidwe ena a neurotransmitter, kuphatikizapo glutamate system. Glutamate ndi neurotransmitter yosangalatsa, ndipo sevoflurane imatha kuchepetsa kutulutsidwa kwake ndi zotsatira zake, zomwe zimathandizira kupsinjika kwa CNS komwe kumawonedwa panthawi ya anesthesia.

Kusamalira Anesthesia

Ngakhale kuti sevoflurane imagwira ntchito popanga opaleshoni, ndiyofunikanso kuisamalira panthawi yonse ya opaleshoni. Anesthesiologists mosamala amalamulira ndende ya sevoflurane m'magazi a wodwalayo kuti atsimikizire zakuya ndi zokhazikika za anesthesia. Kuwongolera kolondola kumeneku kumapangitsa kuti wodwalayo asadziwe za opaleshoniyo komanso zovuta zilizonse.

Kuchira ndi Kuthetsa

Opaleshoniyo ikatha, sevoflurane imathetsedwa, ndipo wodwalayo amayamba kuchira. Kuchotsa sevoflurane m'thupi kumachitika makamaka kudzera mu mpweya. Wodwala akupitirizabe kupuma sevoflurane yotsalira mpaka ndende ya m'magazi ikufika pamlingo wotetezeka kuti adzuke. Izi zimabweretsa kuchira mwachangu komanso kosalala.

Chitetezo ndi Kuyang'anira

Pa nthawi yonse ya makonzedwe a sevoflurane, chitetezo cha odwala ndichofunika kwambiri. Othandizira opaleshoni ndi magulu azachipatala amayang'anitsitsa zizindikiro zofunika, kuphatikizapo kugunda kwa mtima, kuthamanga kwa magazi, ndi mpweya wa okosijeni, kuti atsimikizire kuti wodwalayo amakhalabe wokhazikika panthawi ya opaleshoni. Kuyang'anira mosamala kumeneku kumathandiza kupewa zovuta ndikuwonetsetsa kuti opaleshoni yachitika bwino.

Mapeto

Mwachidule, kachitidwe ka sevoflurane kumakhudza momwe zimakhudzira dongosolo lamanjenje lapakati, komwe kumawonjezera ntchito ya ma neurotransmitters oletsa ngati GABA, kumatchinga ma sign osangalatsa, ndikuwongolera machitidwe ena a neurotransmitter. Izi zimabweretsa kulowetsedwa ndi kukonza kwa anesthesia wamba, kulola odwala kuti achite maopaleshoni momasuka komanso mosatekeseka.

Ngati muli ndi mafunso okhudza sevoflurane kapena mukufuna ogulitsa odalirika pazida zamankhwala ndi mankhwala, chonde musazengereze Lumikizanani nafe. Tili pano kuti tikupatseni zidziwitso ndi chithandizo chomwe mungafune kuti mutsimikizire chitetezo ndi thanzi la odwala anu panthawi ya anesthesia. Thanzi lanu ndi thanzi la odwala anu ndizofunikira kwambiri.