Iyini i-Ticagrelor?

I-Ticagrelor, umuthi ojwayelekile, usebenza njengethuluzi elibalulekile ekuvimbeleni nasekuvimbeleni ukuhlangana kweplatelet ngaphakathi kwegazi. Lo mshini ubalulekile ekugwemeni ukwakheka kwamahlule egazi angafuneki okungase kuholele ezinkingeni ezinzima zempilo. Ake sihlole imininingwane ye-ticagrelor, imisebenzi yayo, nokubaluleka kwayo ekusebenzeni kwezokwelapha.

I-Platelet Aggregation kanye Nemiphumela Yayo

Ukuhlanganiswa kwe-platelet kubhekisela ekuhlanganisweni kwama-platelet egazini, inqubo ebalulekile ye-hemostasis, noma ukuyeka ukopha. Kodwa-ke, lapho ama-platelet ehlangana ngokweqile, kungabangela ukwakheka kwamahlule egazi, kuvimbele ukugeleza kwegazi okubushelelezi emithanjeni. Ukuvinjwa okunjalo kubangela ingozi enkulu, okungase kuholele ezimeni ezifana nokuhlaselwa yinhliziyo, unhlangothi, noma i-pulmonary embolism.

Indima ye-Ticagrelor

I-Ticagrelor isebenza njengemithi ye-antiplatelet, eqondise ngokuqondile i-P2Y12 receptor kumaplatelet. Ngokuvimbela le receptor, i-ticagrelor ivimbela ukusebenza kweplatelet kanye nokuhlanganiswa okulandelayo, ngaleyo ndlela kunciphise ingozi yezenzakalo ze-thrombotic. Le ndlela yenza i-ticagrelor ibe yi-ejenti yokwelapha ebalulekile ekulawuleni izimo lapho ukuvinjelwa kwegazi okungavamile kubangela usongo olukhulu empilweni, njengeziguli ezinomlando we-angina noma i-myocardial infarction (ukuhlasela kwenhliziyo).

Izinkomba zomtholampilo kanye nokusetshenziswa

Odokotela bayanikeza i-ticagrelor ezigulini ezisengozini enkulu yokuba nezinkinga zokujiya kwegazi okungavamile, ikakhulukazi lezo ezinomlando wezenzakalo zenhliziyo nemithambo yegazi njenge-angina noma isifo senhliziyo. Umuthi ngokuvamile unikezwa njengengxenye yohlu lwemithi yokwelapha ephelele okuhloswe ngayo ukuvimbela ezinye izinkinga nokuthuthukisa imiphumela yesiguli. Kodwa-ke, kubalulekile ukuqaphela ukuthi i-ticagrelor ayifanele wonke umuntu, futhi ukusetshenziswa kwayo kufanele kuhlolwe ngokucophelela ngokusekelwe ezicini zesiguli ngasinye kanye nomlando wezokwelapha.

Izinyathelo Zokuqaphela Nokucatshangelwa

Ngaphambi kokwenza noma iyiphi inqubo yokuhlinzwa, iziguli ezithatha i-ticagrelor zelulekwa ukuthi ziyeke ukusetshenziswa kwayo ngaphansi kokuqondiswa kochwepheshe bezempilo. Lesi sinyathelo sokuqapha siyadingeka ukuze unciphise ingozi yokopha ngokweqile ngesikhathi sokuhlinzwa, njengoba imiphumela ye-antiplatelet ye-ticagrelor ingandisa isikhathi sokuphuma kwegazi. Ukwengeza, abahlinzeki bezempilo kumele baqaphe ngokucophelela iziguli ekwelapheni kwe-ticagrelor nganoma yiziphi izimpawu zokuphuma kwegazi noma ukusabela okubi, ukulungisa ukwelashwa njengoba kudingekile ukuze kuqinisekiswe ukuphepha nokusebenza kahle.

Isiphetho

I-Ticagrelor idlala indima ebalulekile ekuvimbeleni amahlule egazi ngokuvimbela ukuhlanganiswa kweplatelet, ngaleyo ndlela kuncishiswe ingozi yezenzakalo ze-thrombotic ezigulini ezisengozini enkulu. Ukusetshenziswa kwayo kubaluleke kakhulu kubantu abanomlando we-angina noma isifo senhliziyo, lapho ukujiya kwegazi okungavamile kubangela usongo olukhulu empilweni. Nokho, kufanele kuqashelwe, ikakhulukazi mayelana nokuyekwa kwayo ngaphambi kokuhlinzwa ukuze kuvinjelwe ukopha kakhulu.

Ukuze uthole ulwazi olwengeziwe nge-ticagrelor nemithi ehlobene, sicela Xhumana nathi. Njengomphakeli wakho omethembayo wemikhiqizo yezemithi, sizimisele ukukunikeza ukwesekwa okuphelele nezisombululo ukuhlangabezana nezidingo zakho zokunakekelwa kwezempilo.