Yintoni iTicagrelor?

Ticagrelor, iyeza eliqhelekileyo, lisebenza njengesixhobo esibalulekileyo ekuthinteleni nasekuthinteleni iplatelet aggregation ngaphakathi kwegazi. Lo matshini ubalulekile ekuthinteleni ukwenziwa kwamahlwili egazi angafunekiyo anokukhokelela kwiingxaki zempilo ezimandundu. Makhe sihlolisise kwiinkcukacha ze-ticagrelor, imisebenzi yayo, kunye nokubaluleka kwayo kwizonyango.

I-Platelet Aggregation kunye neziphumo zayo

Ukudityaniswa kweeplatelet kubhekisa ekudibaneni kweeplatelet egazini, inkqubo ebalulekileyo yehemostasis, okanye ukuyeka ukopha. Noko ke, xa iiplatelets zidibana ngokugqithisileyo, oko kunokubangela ukuba kuvele amahlwili egazi, kuthintele ukuhamba kakuhle kwegazi kwimithambo. Izithintelo ezinjalo zibeka umngcipheko omkhulu, ezinokukhokelela kwiimeko ezifana nokuhlaselwa yintliziyo, ukubetha, okanye i-pulmonary embolism.

Indima yeTicagrelor

I-Ticagrelor isebenza njengeyeza le-antiplatelet, lijolise ngokukodwa kwi-receptor ye-P2Y12 kwiiplatelet. Ngokuthintela le receptor, i-ticagrelor ikhusela ukusebenza kweplatelet kunye nokuhlanganiswa okulandelayo, oko kunciphisa umngcipheko weziganeko ze-thrombotic. Le ndlela yenza i-ticagrelor i-agent ebalulekileyo yonyango ekulawuleni iimeko apho ukuchithwa kwegazi okungaqhelekanga kubangela ingozi enkulu kwimpilo, njengezigulane ezinembali ye-angina okanye i-myocardial infarction (intliziyo).

Iimpawu zeklinikhi kunye nokusetyenziswa

Oogqirha bayalela ticagrelor kwizigulana ezisemngciphekweni omkhulu wokuphuhlisa imiba engaqhelekanga yokuvala igazi, ngakumbi ezo zinembali yeziganeko zentliziyo ezifana ne-angina okanye uhlaselo lwentliziyo. Iyeza lidla ngokulawulwa njengenxalenye yerejimeni yonyango olubanzi olujolise ekuthinteleni iingxaki ezingaphezulu kunye nokuphucula iziphumo zesigulane. Nangona kunjalo, kubalulekile ukuba uqaphele ukuba i-ticagrelor ayifanelekanga kuwo wonke umntu, kwaye ukusetyenziswa kwayo kufuneka kuhlolwe ngokucophelela ngokusekelwe kwizinto ezigulayo kunye nembali yonyango.

ULumkelo kunye neNgqwalasela

Ngaphambi kokwenza nayiphi na inkqubo yokuhlinzwa, izigulane ezithatha i-ticagrelor ziyacetyiswa ukuba ziyeke ukusetyenziswa kwazo phantsi kwesikhokelo sononophelo lwezempilo. Esi silumkiso siyimfuneko ukunciphisa umngcipheko wokuphuma kwegazi ngokugqithiseleyo ngexesha lotyando, njengoko imiphumo ye-antiplatelet ye-ticagrelor inokwandisa ixesha lokuphuma kwegazi. Ukongezelela, ababoneleli bezempilo kufuneka babeke iliso ngokusondeleyo izigulane kwi-ticagrelor therapy nayiphi na imiqondiso yokuphuma kwegazi okanye ukusabela okubi, ukulungelelanisa unyango njengoko kuyimfuneko ukuze kuqinisekiswe ukhuseleko olufanelekileyo kunye nokusebenza kakuhle.

Ukuqukumbela

I-Ticagrelor idlala indima ebalulekileyo ekukhuselweni kwegazi ngokuthintela ukuhlanganiswa kweplatelet, ngaloo ndlela ukunciphisa umngcipheko weziganeko ze-thrombotic kwizigulane ezinobungozi obukhulu. Ukusetyenziswa kwayo kubaluleke kakhulu kubantu abanembali ye-angina okanye ukuhlaselwa yintliziyo, apho ukujika kwegazi okungaqhelekanga kubangela ingozi enkulu kwimpilo. Nangona kunjalo, kufuneka kulumke, ngakumbi malunga nokuyekwa kwayo ngaphambi kokuba kwenziwe utyando ukuthintela ukopha kakhulu.

Ngolwazi oluthe kratya malunga ne-ticagrelor kunye neyeza ezinxulumene nazo, nceda Qhagamshelana nathi. Njengomthengisi wakho othembekileyo weemveliso zamayeza, sizimisele ukubonelela ngenkxaso ebanzi kunye nezisombululo zokuhlangabezana neemfuno zakho zezempilo.