Ngokusho kocwaningo olusha olushicilelwe ku-Journal of the Endocrine Society, umcwaningi uthole ukuthi i-testosterone yandisa ingozi yezimila ze-prostate futhi yandisa imiphumela yokuchayeka kwamakhemikhali e-carcinogenic kumagundane. Unxuse abesilisa abangakatholwa ukuthi bane-hypogonadism Baqaphele lapho benikeza i-testosterone therapy. I-Endocrinology.
Kule minyaka eyishumi edlule, ukusetshenziswa kwe-testosterone kuye kwanda phakathi kwamadoda amadala afuna ukukhulisa amandla nokuzizwa emusha. Ucwaningo olushicilelwe ku-Journal of Clinical Endocrinology and Metabolism luthole ukuthi naphezu kokukhathazeka ngezingozi zenhliziyo nemithambo yegazi, inani lamadoda aseMelika aqala ukwelashwa kwe-testosterone seliphindeke kane kusukela ngo-2000.
The Endocrine Society’s clinical practice guidelines for the treatment of testosterone in adult men recommend that testosterone be prescribed only for men with significantly low hormone levels, decreased libido, erectile dysfunction, or other symptoms of hypogonadism. Online: http://www.endocrine.org/~/ media/endosociety/Files/Publications/Clinical%20Practice%20Guidelines/FINAL-Androgens-in-Men-Standalone.pdf
"Lolu cwaningo lubonisa ukuthi i-testosterone ngokwayo i-carcinogen ebuthakathaka kumagundane abesilisa," kusho umlobi wocwaningo kanye noDkt. Maarten C. Bosland we-DVSc wase-University of Illinois e-Chicago. “Uma ihlanganiswa namakhemikhali e-carcinogenic, i-testosterone idala indawo efanelekile yokuthuthukiswa kwesimila. Uma le miphumela efanayo itholakala kubantu, khona-ke izinkinga zempilo yomphakathi zizoba yimbangela engathi sína.”
Izifundo ezimbili zokuphendula umthamo zihlole izehlakalo zomdlavuza wendlala yesinye kumagundane. Amagundane anikezwe i-testosterone ngedivayisi yokufakelwa ekhishwa okuqhubekayo. Ngaphambi kokujova i-testosterone kumagundane, ezinye izilwane zazijovwe ngekhemikhali ye-carcinogenic i-N-nitroso-N-methylurea (MNU). Lawa magundane aqhathaniswe neqembu elilawulayo elathola i-MNU kodwa lafaka idivayisi yokukhishwa okuqhubekayo engenalutho.
Phakathi kwamagundane athola i-testosterone ngaphandle kwamakhemikhali e-carcinogenic, i-10% kuya ku-18% yaba nomdlavuza wendlala yesinye. Ukwelashwa kwe-testosterone kuphela akuzange kubangele izimila ezithile kwezinye izingosi, kodwa uma kuqhathaniswa namagundane okulawula, kubangele ukwanda okuphawulekayo kwenani lamagundane anezimila ezimbi kunoma iyiphi indawo. Uma amagundane evezwe ku-testosterone nama-carcinogens, lokhu kwelashwa kubangela ama-50% kuya ku-71% wamagundane ukuthi abe nomdlavuza we-prostate. Ngisho noma umthamo we-hormone uphansi kakhulu ukukhulisa izinga le-testosterone egazini, ingxenye yamagundane isahlushwa izimila ze-prostate. Izilwane ezichayeke kumakhemikhali e-carcinogenic kodwa hhayi ku-testosterone azizange zibe nomdlavuza we-prostate.
"Ngenxa yokuthi ukuthuthukiswa kokwelashwa kwe-testosterone kusha, futhi umdlavuza wendlala yesinye isifo esikhula kancane kancane, okwamanje akukho datha yokunquma ukuthi i-testosterone iyandisa yini ingozi yomdlavuza we-prostate kubantu," kusho uBoslan. "Nakuba kuye kwenziwa ucwaningo lwabantu, kuwukuhlakanipha ukukhawulela imiyalelo ye-testosterone emadodeni ane-symptomatic hypogonadism yomtholampilo, nokugwema amadoda ukusebenzisa i-testosterone ngezinjongo ezingezona ezokwelapha, okuhlanganisa ukubhekana nezimpawu ezivamile zokuguga."
Ucwaningo olunesihloko esithi "Ukwelashwa kwe-Testosterone kungumgqugquzeli wesimila osebenzayo we-prostate yamagundane" kushicilelwe ku-inthanethi ngaphambi kokuphrinta.
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Isikhathi sokuthumela: Sep-09-2021