Iyini i-Theophylline?

I-Theophylline, ilungu lesigaba sezidakamizwa ze-xanthine, lidlala indima ebalulekile ekulawuleni izimo zokuphefumula, ikakhulukazi isifuba somoya kanye nesifo esingamahlalakhona sokuvimba kwamaphaphu (COPD). Lo muthi usebenza njenge-bronchodilator, unikeza impumuzo kubantu abanenkinga yokuphefumula. Ngaphandle kokusetshenziswa kwayo okuyinhloko ezinkingeni zokuphefumula, i-Theophylline iphinde ibonise imiphumela enhliziyweni nasesimisweni sezinzwa esimaphakathi, okuyenza ibe umuthi oguquguqukayo ezimeni ezithile zezokwelapha.

Ukuqonda i-Theophylline njenge-Bronchodilator

I-Bronchodilation Mechanism

I-Theophylline isebenzisa imiphumela yayo ye-bronchodilator ngokuphumuza nokwandisa imigudu yokuphefumula emaphashini. Ifinyelela lokhu ngokuvimbela isenzo se-phosphodiesterase, i-enzyme enesibopho sokudiliza i-cyclic AMP (cAMP). Amazinga aphezulu e-cAMP aholela ekuphumuleni kwemisipha ebushelelezi, okuholela ekwandeni kwamaphaseji omoya we-bronchial. Lo mshini wenza kube lula ukugeleza komoya, okwenza ukuphefumula kube lula kubantu abanezimo zokuphefumula.

Izimo Zokuphefumula kanye ne-Theophylline

Ukusetshenziswa okuyinhloko kwe-Theophylline kusekulawuleni isifuba somoya kanye ne-COPD. Ku-asthma, isiza ekwehliseni i-bronchoconstriction, kuyilapho i-COPD, isiza ekwehliseni ukumelana komoya. I-Theophylline ivame ukunikezwa lapho amanye ama-bronchodilator, njengama-beta-agonists noma ama-anticholinergics, angase anganikezi ukukhululeka okwanele.

Imiphumela Eyengeziwe ye-Theophylline

Umthelela Wenhliziyo

Ngaphandle kwezinzuzo zayo zokuphefumula, i-Theophylline iphinde ithinte isimiso senhliziyo nemithambo yegazi. Kungashukumisa inhliziyo, okuholela ekwandeni kokushaya kwenhliziyo namandla okufinyeza. Lokhu kwenza kubeluleka ukuthi ochwepheshe bezokunakekelwa kwempilo baqaphe ngokucophelela iziguli, ikakhulukazi lezo ezinezimo zenhliziyo ezivele zikhona, ngesikhathi sokwelashwa kwe-Theophylline.

Imiphumela Yesistimu Yezinzwa Emaphakathi

I-TheophyllineIthonya lidlulela ohlelweni lwezinzwa olumaphakathi, lapho lingashukumisa izikhungo zokuphefumula ebuchosheni. Lokhu kushukumisa kuthuthukisa isifiso sokuphefumula, kube nomthelela ekusebenzeni komuthi ekuxazululeni izinkinga zokuphefumula.

Ukucatshangelwa Komtholampilo kanye Nesilinganiso

Ukwelashwa Okuzimele

Ngenxa yokuhlukahluka kokuphendula kwesiguli kanye ne-metabolism, umthamo we-Theophylline udinga umuntu ngamunye. Izinto ezinjengobudala, isisindo, kanye nemithi ehambisanayo zingathonya indlela umzimba osebenza ngayo i-Theophylline. Ukuqapha njalo amazinga egazi kubalulekile ukuze kuqinisekiswe ukusebenza ngempumelelo kokwelapha kuyilapho ugwema ubuthi obungaba khona.

Engase Engase Side Effects

Njenganoma yimuphi umuthi, i-Theophylline ingabangela imiphumela emibi. Imiphumela emibi evamile ihlanganisa isicanucanu, ikhanda elibuhlungu, nokuqwasha. Imiphumela emibi kakhulu, njengokushaya kwenhliziyo okusheshayo noma ukuquleka, idinga ukunakekelwa kwezokwelapha ngokushesha.

Isiphetho

Sengiphetha, indima ka-Theophylline njenge-bronchodilator iyenza ibe wusizo ekulawuleni izimo zokuphefumula. Ikhono layo lokuphumula nokunweba imigudu yokuphefumula linikeza impumuzo kubantu abanenkinga yesifuba somoya kanye ne-COPD. Kodwa-ke, ochwepheshe bezokunakekelwa kwempilo kufanele baqaphe iziguli ngenxa yemiphumela engaba khona yenhliziyo nemithambo yegazi. Izinhlelo zokwelashwa ezizimele kanye nokuhlola okuvamile kuqinisekisa imiphumela emihle yokwelapha kuyilapho kunciphisa imiphumela emibi.

Ukuze uthole ulwazi olwengeziwe mayelana ne-Theophylline noma ukubuza mayelana nokutholakala kwayo, sicela Xhumana nathi. Sizinikele ekuhlinzekeni ngemithi ebalulekile kanye nokweseka impilo yokuphefumula. Njengomphakeli othembekile, silwela ukuhlangabezana nezidingo ezihlukahlukene zabahlinzeki bezempilo neziguli ngokufanayo.