Theophylline, ilungu leklasi ye-xanthine yeziyobisi, idlala indima ebalulekileyo ekulawuleni iimeko zokuphefumla, ngakumbi i-asthma kunye nesifo esingapheliyo se-pulmonary (COPD). Eli yeza lisebenza njenge-bronchodilator, linika isiqabu kubantu abanengxaki yokuphefumla. Ngaphandle kokusetyenziswa kwayo okuphambili kukuphazamiseka kokuphefumla, iTheophylline ikwabonisa iziphumo entliziyweni nakwinkqubo yemithambo-luvo, iyenza ibe liyeza eliguquguqukayo kwiimeko ezithile zonyango.
Ukuqonda iTheophylline njengeBronchodilator
Inkqubo yeBronchodilation
I-Theophylline yenza iziphumo zayo ze-bronchodilator ngokuphumla kunye nokwandisa iindlela zomoya kwimiphunga. Ifezekisa oku ngokuthintela isenzo se-phosphodiesterase, i-enzyme ejongene nokuphula i-cyclic AMP (cAMP). Amanqanaba aphakamileyo e-cAMP akhokelela ekuphumleni kwemisipha egudileyo, okukhokelela ekuvulekeni kweepaseji zomoya we-bronchial. Lo matshini wenza kube lula ukuhamba komoya, okwenza ukuphefumla kube lula kubantu abaneemeko zokuphefumla.
Iimeko zokuphefumla kunye neTheophylline
Ukusetyenziswa okuphambili kweTheophylline kulawulo lwe-asthma kunye neCOPD. Kwi-asthma, inceda ukunciphisa i-bronchoconstriction, ngelixa i-COPD, inceda ekunciphiseni ukuxhathisa kwendlela yomoya. I-Theophylline idla ngokumiselwa xa ezinye ii-bronchodilators, ezifana ne-beta-agonists okanye i-anticholinergics, zingenakubonelela ngokwaneleyo.
Iimpembelelo ezongezelelweyo zeTheophylline
Impembelelo yentliziyo
Ngaphandle kweenzuzo zayo zokuphefumla, iTheophylline ikwachaphazela inkqubo ye-cardiovascular system. Inokuvuselela intliziyo, ekhokelela ekwandeni kwesantya sentliziyo kunye namandla okunciphisa. Oku kwenza ukuba kubaluleke kakhulu kwiingcali zezempilo ukuba zibeke iliso ngononophelo izigulana, ngakumbi ezo zineemeko zentliziyo esele zikhona, ngexesha lonyango lwe-Theophylline.
Iziphumo zeNkqubo yeNervous esembindini
Theophylline's impembelelo idlulela kwinkqubo yemithambo-luvo, apho inokuvuselela amaziko okuphefumla ebuchotsheni. Olu vuselelo luphucula ukuqhubela phambili kokuphefumla, lunegalelo ekusebenzeni kwamayeza ekujonganeni nemiba yokuphefumla.
Iingqwalasela zeklinikhi kunye nomthamo
Unyango lomntu ngamnye
Ngenxa yokwahluka kwempendulo yesigulane kunye ne-metabolism, idosi ye-Theophylline idinga umntu ngamnye. Izinto ezinje ngobudala, ubunzima, kunye neyeza ezihambelanayo zinokuchaphazela indlela umzimba oqhuba ngayo i-Theophylline. Ukubeka iliso rhoqo kumanqanaba egazi kubalulekile ukuqinisekisa ukusebenza konyango ngelixa uphepha ubuthi obunokubakho.
Iimpembelelo ezinokuba khona
Njengawo nawaphi na amayeza, iTheophylline inokubangela iziphumo ebezingalindelekanga. Iziphumo ebezingalindelekanga eziqhelekileyo ziquka isicaphucaphu, intloko ebuhlungu, nokungalali. Iziphumo ebezingalindelekanga ezimandundu, ezinjengokubetha kwentliziyo ngokukhawuleza okanye ukuxhuzula, zifuna ukhathalelo lwezonyango olukhawulezileyo.
Ukuqukumbela
Ekugqibeleni, indima ye-Theophylline njenge-bronchodilator yenza ukuba ibe yinto ebalulekileyo ekulawuleni iimeko zokuphefumula. Ukukwazi kwayo ukuphumla kunye nokwandisa iindlela zomoya kunika isiqabu kubantu abanengxaki yesifuba kunye neCOPD. Nangona kunjalo, abaqeqeshi bezempilo kufuneka baphaphe ekubekeni iliso kwizigulana ngenxa yeziphumo zentliziyo kunye nenkqubo ye-nervous central. Izicwangciso zonyango zomntu ngamnye kunye novavanyo oluqhelekileyo luqinisekisa iziphumo ezichanekileyo zonyango ngelixa kuncitshiswa iziphumo ebezingalindelekanga.
Ngolwazi oluthe vetshe malunga neTheophylline okanye ukubuza malunga nokufumaneka kwayo, nceda Qhagamshelana nathi. Sizinikezele ekunikeni amayeza ayimfuneko kunye nenkxaso kwimpilo yokuphefumla. Njengomboneleli othembekileyo, sizama ukuhlangabezana neemfuno ezahlukeneyo zababoneleli bezempilo kunye nezigulana ngokufanayo.
Ixesha lokuposa: Feb-19-2024