Ka Hoʻomaopopo ʻana i ka Pentoxifylline: He Manaʻo Kūʻē

Pentoxifylline he lāʻau lapaʻau no ka papa o nā lāʻau i ʻike ʻia he xanthine derivatives. Hoʻohana maʻamau ia no ka mālama ʻana i nā maʻi like ʻole o ke kahe koko, e komo pū me nā maʻi vascular peripheral, intermittent claudication, a me nā ʻeha venous. Hāʻawi kēia ʻatikala i kahi hiʻohiʻona piha o ka pentoxifylline, me kāna ʻano hana, ka hoʻohana therapeutic, nā hopena ʻaoʻao, a me ka mālama ʻana.

Mechanism of Action

Hoʻohana ka Pentoxifylline i kāna mau hopena therapeutic ma mua o ka hoʻomaikaʻi ʻana i ke kahe koko a me ke kahe. Hoʻohana ia ma ke kāohi ʻana i ka enzyme phosphodiesterase, kahi e hoʻonui ai i nā pae o ka cyclic adenosine monophosphate (cAMP) i loko o nā cell. ʻO nā pae kiʻekiʻe o ka cAMP e alakaʻi i ka hoʻomaha ʻana o ka ʻiʻo maʻemaʻe vascular a me ka dilation o nā kīʻaha koko, e hoʻomaikaʻi ai i ke kahe koko i nā wahi i hoʻopilikia ʻia. Hoʻohui ʻia, hoʻemi ka pentoxifylline i ka viscosity o ke koko, me ka liʻiliʻi o ka hana ʻana i nā clots a me ka hoʻomaikaʻi ʻana i ka maʻalahi o nā ʻulaʻula ʻulaʻula.

Hoohana Lapaau

ʻO ka maʻi vascular peripheral (PVD): ʻO ka Pentoxifylline ka mea maʻamau i kuhikuhi ʻia no ka mālama ʻana i ka maʻi vascular peripheral, kahi maʻi i hōʻike ʻia e ka hōʻemi ʻana a i ʻole ka paʻa ʻana o nā kīʻaha koko i loko o nā lima, nā wāwae, a i ʻole nā ​​ʻāpana ʻē aʻe o ke kino. Ma ka hoʻomaikaʻi ʻana i ke kahe koko i nā wahi i hoʻopilikia ʻia, kōkua ka pentoxifylline i ka hoʻēmi ʻana i nā hōʻailona e like me ka ʻeha, cramping, a me ka numbness e pili ana me PVD.

Intermittent Claudication: ʻO ka intermittent claudication kahi hōʻailona o ka maʻi o ke aʻaʻa peripheral (PAD) i hōʻike ʻia e ka ʻeha a i ʻole ka ʻūhā o nā wāwae i ka wā o ka hoʻoikaika kino. Kuhi pinepine ʻia ʻo Pentoxifylline e hōʻoluʻolu i nā hōʻailona a hoʻomaikaʻi i ka hoʻomaʻamaʻa hoʻomaʻamaʻa ʻana i nā poʻe me ka intermittent claudication ma o ka hoʻonui ʻana i ke kahe koko i nā wāwae a me ka hōʻemi ʻana i ka ischemia muscle.

Venous Ulcers: Hiki ke hoʻohana ʻia ka Pentoxifylline i ka mālama ʻana i nā ʻeha venous, ʻo ia nā ʻeha hāmama e ulu ana ma nā wāwae a i ʻole nā ​​wāwae ma muli o ke kahe ʻana o ka venous circulation. Ma ka hoʻonui ʻana i ke kahe koko a me ka oxygenation kiko, kōkua ka pentoxifylline i ka ho'ōla ʻana i ka ʻeha a hoʻoikaika i ka pani ʻana o nā ʻeha venous.

Hiki i nā hopena ʻaoʻao

ʻOiai pentoxifylline ʻae maikaʻi ʻia, hiki ke hana i kekahi mau hopena ʻaoʻao i kekahi poʻe. Hiki i nā hopena ʻaoʻao maʻamau ke komo i ka nausea, ka luaʻi ʻana, ka ʻeha o ka ʻōpū, ka noʻonoʻo, ke poʻo, a me ka ʻula. ʻO kēia mau hopena ʻaoʻao maʻamau ka maʻalahi a me ka transient, e hoʻoholo iā lākou iho i ka hoʻoponopono ʻana o ke kino i ka lāʻau. Eia nō naʻe, i nā hihia kakaʻikahi, hiki ke loaʻa nā hopena ʻoi aku koʻikoʻi e like me ka maʻi maʻi, ka puʻuwai ʻole, a me ke kahe koko, e koi ana i ka lāʻau lapaʻau koke.

Hoʻomalu

Ka hāpai ʻana a me ka lactation: Pono e hoʻohana ʻia ka Pentoxifylline me ka makaʻala i nā wahine hāpai a i ʻole nā ​​​​mea hānai, no ka mea ʻaʻole i hoʻokumu ʻia kona palekana i kēia mau heluna. Hiki i nā mea mālama olakino ke kaupaona i nā pono kūpono e pili ana i nā pilikia ma mua o ka kuhikuhi ʻana i ka pentoxifylline i nā poʻe hāpai a i ʻole ka lactating.

Hoʻopili i nā lāʻau: Hiki i ka Pentoxifylline ke launa pū me kekahi mau lāʻau, me nā anticoagulants, nā lāʻau antiplatelet, a me ka theophylline. ʻO ka hoʻohana like ʻana o ka pentoxifylline me kēia mau lāʻau lapaʻau hiki ke hoʻonui i ka hopena o ke koko a i ʻole nā ​​​​hopena ʻino ʻē aʻe. He mea nui e hoʻomaopopo i nā mea mālama olakino e pili ana i nā lāʻau lapaʻau āpau, nā mea hoʻohui, a me nā mea kanu lāʻau i lawe ʻia e pale aku i nā pilina pili.

Manao Pani

I ka hōʻuluʻulu ʻana, ʻo ka pentoxifylline kahi lāʻau lapaʻau i hoʻohana mua ʻia no ka mālama ʻana i nā maʻi circulatory e like me ka maʻi vascular peripheral, intermittent claudication, a me nā ʻeha venous. Ma ka hoʻomaikaʻi ʻana i ke kahe koko a me ke kahe ʻana, kōkua ka pentoxifylline e hōʻoluʻolu i nā hōʻailona a hoʻoikaika i ka hoʻōla ʻana i nā poʻe me kēia mau kūlana. ʻOiai e ʻae maikaʻi ʻia, hiki i ka pentoxifylline ke hana i nā hopena ʻaoʻao i kekahi poʻe a pono e hoʻohana me ka akahele i kekahi mau heluna kanaka. Inā he nīnau kāu e pili ana i ka pentoxifylline a i ʻole ka hoʻohana ʻana, e ʻoluʻolu e ʻoluʻolu kāhea iā mā˚ou. Eia mākou e hāʻawi i ka ʻike a me ke kākoʻo e pili ana i kēia lāʻau lapaʻau a me kona loaʻa ʻana mai kā mākou mea hoʻolako hilinaʻi.