Ukuqonda i-Pentoxifylline: Uhlolojikelele Oluphelele

I-Pentoxifylline umuthi ongokwesigaba sezidakamizwa ezaziwa ngokuthi yi-xanthine derivatives. Ngokuvamile kunqunyelwe ukwelapha izifo ezihlukahlukene zokujikeleza kwegazi, kuhlanganise nesifo se-vascular peripheral, i-claudication ephakathi, kanye nezilonda ze-venous. Le ndatshana ihlinzeka ngemininingwane ebanzi ye-pentoxifylline, okuhlanganisa indlela yayo yokusebenza, ukusetshenziswa kokwelapha, imiphumela engemihle engaba khona, kanye nezinyathelo zokuphepha.

Indlela Yokwenza

I-Pentoxifylline inemiphumela yayo yokwelapha ngokuyinhloko ngokwenza ngcono ukugeleza kwegazi nokujikeleza kwegazi. Isebenza ngokuvimbela i-enzyme phosphodiesterase, okuholela emazingeni akhulayo e-cyclic adenosine monophosphate (cAMP) ngaphakathi kwamaseli. Amazinga e-cAMP aphakeme aholela ekuxegisweni kwemisipha ebushelelezi yemithambo yegazi kanye nokunwebeka kwemithambo yegazi, ngaleyo ndlela enze ngcono ukugeleza kwegazi ezindaweni ezithintekile. Ngaphezu kwalokho, i-pentoxifylline yehlisa i-viscosity yegazi, ikwenze kube mancane amathuba okwakheka amahlule futhi ithuthukise ukuguquguquka kwamangqamuzana egazi abomvu.

Ukusetshenziswa Kwezokwelapha

I-Pentoxifylline (PVD): I-Pentoxifylline ivame ukunqunywa ekwelapheni isifo se-peripheral vascular disease, isimo esibonakala ngokuncipha noma ukuvaleka kwemithambo yegazi ezingalweni, emilenzeni, noma kwezinye izingxenye zomzimba. Ngokuthuthukisa ukugeleza kwegazi ezindaweni ezithintekile, i-pentoxifylline isiza ekudambiseni izimpawu ezinjengobuhlungu, ukuminca, nokuba ndikindiki okuhlobene ne-PVD.

I-Intermittent Claudication: I-Claudication eqhubekayo iwuphawu lwe-peripheral artery disease (PAD) ebonakala ngobuhlungu noma ukugoqa emilenzeni ngesikhathi sokusebenza ngokomzimba. I-Pentoxifylline ivame ukunqunywa ukuze kudambise izimpawu futhi kuthuthukiswe ukubekezelelana kokuzivocavoca kubantu abane-claudication ngezikhathi ezithile ngokwandisa ukugeleza kwegazi emilenzeni kanye nokunciphisa i-ischemia yemisipha.

I-Venous Ulcers: I-Pentoxifylline ingase futhi isetshenziswe ekulawulweni kwezilonda ze-venous, okuyizilonda ezivulekile ezivela emilenzeni noma ezinyaweni ngenxa yokuphazamiseka kokujikeleza kwe-venous. Ngokuthuthukisa ukugeleza kwegazi kanye ne-oxygenation yezicubu, i-pentoxifylline isiza ekwelapheni kwesilonda futhi ikhuthaze ukuvalwa kwezilonda ze-venous.

Engase Engase Side Effects

Ngenkathi i-pentoxifylline ngokuvamile ibekezelelwa kahle, ingase ibangele imiphumela ethile engemihle kwabanye abantu. Imiphumela engemihle evamile ingase ihlanganise isicanucanu, ukuhlanza, ukungakhululeki kwesisu, isiyezi, ikhanda elibuhlungu, nokushaywa umoya. Le miphumela engemihle ivamise ukuba mnene futhi iyedlula, iyazixazulula yona njengoba umzimba ujwayela umuthi. Kodwa-ke, ezimweni ezingavamile, imiphumela emibi kakhulu efana nokungezwani komzimba, ukushaya kwenhliziyo okungavamile, nokopha kungase kwenzeke, okudinga ukunakekelwa ngokushesha kwezokwelapha.

Izinyathelo zokuzivikela

Ukukhulelwa Nokuncelisa: I-Pentoxifylline kufanele isetshenziswe ngokuqapha kwabesifazane abakhulelwe noma abancelisa ibele, njengoba ukuphepha kwayo akukasungulwa kulezi zibalo. Abahlinzeki bezempilo bangase balinganise izinzuzo ezingaba khona ngokumelene nezingozi ngaphambi kokunquma i-pentoxifylline kubantu abakhulelwe noma abancelisayo.

Ukusebenzisana Kwezidakamizwa: I-Pentoxifylline ingase ihlanganyele nemithi ethile, okuhlanganisa ama-anticoagulants, izidakamizwa ze-antiplatelet, ne-theophylline. Ukusetshenziswa kanyekanye kwe-pentoxifylline nale mithi kungandisa ingozi yokopha noma eminye imiphumela emibi. Kubalulekile ukwazisa abahlinzeki bezempilo mayelana nayo yonke imithi, izithasiselo, nemikhiqizo yamakhambi ethathwayo ukuze kugwenywe ukusebenzisana okungenzeka.

Ukuvala Imicabango

Kafushane, i-pentoxifylline umuthi osetshenziswa ikakhulukazi ekwelapheni ukuphazamiseka kokujikeleza kwegazi okunjenge-peripheral vascular disease, i-intermittent claudication, nezilonda ze-venous. Ngokuthuthukisa ukugeleza kwegazi nokujikeleza kwegazi, i-pentoxifylline isiza ekudambiseni izimpawu futhi ikhuthaze ukuphulukiswa kubantu abanalezi zimo. Nakuba ngokuvamile ibekezelelwa kahle, i-pentoxifylline ingase ibangele imiphumela engemihle kwabanye abantu futhi kufanele isetshenziswe ngokuqapha emiphakathini ethile. Uma unemibuzo mayelana ne-pentoxifylline noma ukusetshenziswa kwayo, sicela ungangabazi Xhumana nathi. Silapha ukuze sinikeze ulwazi nokwesekwa mayelana nalo muthi nokutholakala kwawo kubahlinzeki bethu abathembekile.