Ukuqonda iPentoxifylline: Isishwankathelo esiBanzi

Ipentoxifylline liyeza leqela lamachiza aziwa ngokuba yi-xanthine derivatives. Ngokuqhelekileyo imiselwe unyango lweengxaki ezahlukeneyo zokujikeleza kwegazi, kubandakanywa nesifo se-vascular peripheral, i-intermittent claudication, kunye nezilonda ze-venous. Eli nqaku libonelela ngesishwankathelo esibanzi se-pentoxifylline, kubandakanya indlela yokusebenza kwayo, ukusetyenziswa konyango, iziphumo ebezingalindelekanga kunye nezilumkiso.

Indlela yokwenza

I-Pentoxifylline yenza iziphumo zayo zonyango ngokuphucula ukuhamba kwegazi kunye nokujikeleza. Isebenza ngokuthintela i-enzyme i-phosphodiesterase, ekhokelela ekunyuseni kwamanqanaba e-cyclic adenosine monophosphate (cAMP) ngaphakathi kweeseli. Amanqanaba e-cAMP aphakamileyo akhokelela ekuphumleni kwe-vascular smooth muscle kunye nokwandiswa kwemithambo yegazi, ngaloo ndlela kuphuculwe ukuhamba kwegazi kwiindawo ezichaphazelekayo. Ukongeza, i-pentoxifylline yehlisa i-viscosity yegazi, isenza ukuba kube lula ukwenza amahlwili kunye nokuphucula ukuguquguquka kweeseli ezibomvu zegazi.

Ukusetyenziswa koNyango

I-Pentoxifylline ye-Pentoxifylline ngokuqhelekileyo imiselwe unyango lwe-peripheral vascular disease, imeko ebonakaliswe ngokunciphisa okanye ukuvaleka kwemithambo yegazi ezingalweni, emilenzeni, okanye kwezinye iindawo zomzimba. Ngokuphucula ukuhamba kwegazi kwiindawo ezichaphazelekayo, i-pentoxifylline inceda ukunciphisa iimpawu ezinjengeentlungu, ukuqaqanjelwa, kunye nokuba ndindisholo okuhambelana ne-PVD.

I-Intermittent Claudication: I-Intermittent claudication yimpawu ye-peripheral artery disease (PAD) ebonakaliswe yintlungu okanye ukunyanzeliswa kwemilenze ngexesha lomsebenzi womzimba. I-Pentoxifylline ihlala imiselwe ukukhulula iimpawu kunye nokuphucula ukunyamezela umthambo kubantu abane-claudication engapheliyo ngokwandisa ukuhamba kwegazi emilenzeni kunye nokunciphisa i-ischemia yemisipha.

Izilonda ze-Venus: I-Pentoxifylline inokusetyenziselwa ukulawula izilonda ze-venous, ezizizilonda ezivulekileyo ezikhula emilenzeni okanye ezinyaweni ngenxa yokuphazamiseka kokujikeleza kwe-venous. Ngokwandisa ukuhamba kwegazi kunye ne-oxygenation yezicubu, i-pentoxifylline inceda ekuphiliseni amanxeba kwaye ikhuthaza ukuvalwa kwezilonda ze-venous.

Iimpembelelo ezinokuba khona

Ngelixa pentoxifylline Inyamezeleka ngokubanzi, inokubangela iziphumo ebezingalindelekanga ezithile kwabanye abantu. Iziphumo ebezingalindelekanga eziqhelekileyo zinokubandakanya isicaphucaphu, ukugabha, ukungakhululeki kwesisu, isiyezi, intloko ebuhlungu, kunye nokugungxulwa. Ezi ziphumo bezingalindelekanga zihlala zithambile kwaye zidlula, zizisombulula ngokwazo njengoko umzimba ulungelelanisa amayeza. Nangona kunjalo, kwiimeko ezinqabileyo, iziphumo ezibi kakhulu ezifana nokungahambi kakuhle, ukubetha kwentliziyo okungaqhelekanga, kunye nokopha kunokuthi kwenzeke, okudinga unyango olukhawulezileyo.

Ukulumkela

Ukukhulelwa kunye nokuncancisa: I-Pentoxifylline kufuneka isetyenziswe ngononophelo kubasetyhini abakhulelweyo okanye abancancisayo, njengoko ukhuseleko lwayo alukasekwa kwaba bantu. Ababoneleli ngezempilo banokujonga izibonelelo ezinokuthi zibe kho ngokubhekiselele kumngcipheko phambi kokuba banike i-pentoxifylline kubantu abakhulelweyo okanye abancancisayo.

Ukusebenzisana kweziyobisi: I-Pentoxifylline inokunxibelelana namayeza athile, kuquka i-anticoagulants, i-antiplatelet drug, kunye ne-theophylline. Ukusetyenziswa ngaxeshanye kwepentoxifylline ngala mayeza kunokonyusa umngcipheko wokopha okanye ezinye iziphumo ezibi. Kubalulekile ukwazisa ababoneleli bezempilo malunga nawo onke amayeza, izongezo, kunye neemveliso zamachiza ezithathwayo ukuphepha ukusebenzisana okunokwenzeka.

Iingcamango zokuvala

Ngamafutshane, i-pentoxifylline liyeza elisetyenziswa ikakhulu kunyango lokuphazamiseka kokujikeleza kwegazi okunje nge-peripheral vascular disease, i-intermittent claudication, kunye nezilonda ze-venous. Ngokuphucula ukuhamba kwegazi kunye nokujikeleza, i-pentoxifylline inceda ukunciphisa iimpawu kunye nokukhuthaza ukuphilisa kubantu abanezi meko. Ngelixa inyamezeleke ngokubanzi, i-pentoxifylline inokubangela iziphumo ebezingalindelekanga kwabanye abantu kwaye kufuneka isetyenziswe ngononophelo kubantu abathile. Ukuba unayo nayiphi na imibuzo malunga nepentoxifylline okanye ukusetyenziswa kwayo, nceda ungalibazisi Qhagamshelana nathi. Silapha ukubonelela ngolwazi kunye nenkxaso malunga neli yeza kunye nokufumaneka kwalo kubaboneleli bethu abathembekileyo.