Lýsing
Olprinone er sértækur fosfódíesterasa 3 (PDE3) hemill. Olprinone er notað sem hjartadrepandi lyf með jákvæðum inotropic og æðavíkkandi áhrifum. Greint hefur verið frá því að olprinón bæti örhringrásina og dregur úr bólgu. Olprinone er oft notað til að auka útfall hjartans eftir hjarta- og lungahjáveitu (CPB). Olprinón var gefið með innrennsli á hraðanum 0,2 μg/kg/mín þegar frávenning frá CPB var hafin. Olprinone hefur einnig sýnt öflug andoxunar- og bólgueyðandi áhrif í oxunar-lungnaskaða af völdum mekoníums.
Tæknilegar upplýsingar:
Samheiti: Olprinónhýdróklóríð-Loprinónhýdróklóríð;3-pýridínkarbónítríl,1,2-díhýdró-5-(imidasó(1,2-a)pýridín-6-ýl)-6-metýl-2-o;e1020;xo-,einhýdróklóríð,einhýdrat;OLPRINONEHCL;
Vottorð: GMP vottorð, CFDA
Sameindaformúla: C14H10N4O • HCl
Þyngd formúlu: 286,7
Hreinleiki: ≥98%
Samsetning (Biðja um breytingu á samsetningu)
Kanónískt bros: CC1=C(C=C(C(=O)N1)C#N)C2=CN3C=CN=C3C=C2.Cl
Upplýsingar um sendingu og geymslu:
Geymsla: -20°C
Sending: Herbergishiti á meginlandi Bandaríkjanna; getur verið mismunandi annars staðar
Stöðugleiki: ≥ 4 ár
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