Incazelo
I-Olprinone iyi-selective phosphodiesterase 3 (PDE3) inhibitor. I-Olprinone isetshenziswa njenge-ejenti ye-cardiotonic enemiphumela emihle ye-inotropic ne-vasodilating. Kubikwa ukuthi i-Olprinone yenza ngcono i-microcirculation futhi inciphise ukuvuvukala. I-Olprinone ivame ukusetshenziselwa ukwandisa ukuphuma kwenhliziyo ngemva kokudlula kwe-cardiopulmonary bypass (CPB). I-Olprinone yafakwa ngenani lika-0.2 μg/kg/min lapho kuqaliswa ukulunyulwa kwe-CPB. I-Olprinone iphinde yabonisa imiphumela enamandla ye-antioxidative ne-anti-inflammatory ekulimazeni kwamaphaphu okubangelwa yi-meconium.
Ulwazi Lokusebenza:
Omqondofana: I-Olprinonehydrochloride-Loprinonehydrochloride;3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o;e1020;xo-,i-monohydrochloride,i-monohydrate;OLPRINONEHCL;
Isitifiketi: Isitifiketi se-GMP, i-CFDA
I-Molecular Formula: C14H10N4O • I-HCl
Isisindo sefomula: 286.7
Ubumsulwa :≥98%
Ukwakhiwa(Cela ukuguqulwa kokwakhiwa)
I-Canonical AMAMAMOMO: CC1=C(C=C(C(=O)N1)C#N)C2=CN3C=CN=C3C=C2.Cl
Ulwazi Lokuthumela Nokugcinwa:
Isitoreji: -20°C
Ukuthumela Ngemikhumbi: Izinga lokushisa Legumbi ezwekazini lase-US; zingahluka kwenye indawo
Ukuzinza: ≥ iminyaka emi-4
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